Sugi Predict

Sugi Predict / Compounds / SCHEMBL3756111

SCHEMBL3756111

SCHEMBL3756111

Cc1c(-c2ccccc2)[c]nc(N)c1N1CCCCC1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADORA2A P29274 2/20 0.40
▸ HTT P42858 2/20 0.39
▸ HSD17B10 Q99714 2/20 0.39
▸ USP2 O75604 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ KDM4E B2RXH2 2/20 0.39
▸ ALDH1A1 P00352 2/20 0.39
▸ HPGD P15428 2/20 0.39
▸ ADRA2A P08913 1/20 0.39
▸ RXFP1 Q9HBX9 1/20 0.39
▸ MAT2A P31153 4/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ GLA P06280 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ ALOX15 P16050 1/20 0.37
▸ DHFR P00374 2/20 0.36
▸ NPY5R Q15761 1/20 0.36
▸ KEAP1 Q14145 1/20 0.35
▸ CYP1A2 P05177 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3759089 0.99 ADORA2A (0.39) ADORA2AHTTHSD17B10USP2LMNA
SCHEMBL3762351 0.82 KMT2A (0.38) HSD17B10USP2LMNATSHRKDM4E
SCHEMBL3760546 0.81 LRRK2 (0.37) HSD17B10TSHRKDM4EALDH1A1HPGD
SCHEMBL3754966 0.78 CNR1 (0.38) HSD17B10USP2LMNATSHRKDM4E
SCHEMBL3761663 0.74 KMT2A (0.49) HTTHSD17B10USP2TSHRKDM4E
SCHEMBL3752036 0.72 HTR1A (0.41) TSHRALDH1A1HPGDKMT2ANPY5R
SCHEMBL3760334 0.72 CKS1B (0.39) HSD17B10USP2LMNATSHRKDM4E
SCHEMBL3754790 0.71 NPY5R (0.43) HTTHSD17B10LMNATSHRKDM4E
SCHEMBL3757772 0.71 HSD17B10 (0.40) ADORA2AHTTHSD17B10USP2LMNA
SCHEMBL3759007 0.71 HTT (0.48) HTTHSD17B10USP2TSHRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2029570-B1 FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS UCB PHARMA SA (BE) 2014-10-15 — — EP disclosed
US-8324204-B2 Fused thiophene derivatives as kinase inhibitors UCB PHARMA SA (BE) 2012-12-04 — — US disclosed
US-20100305066-A1 Fused Thiophene Derivatives as Kinase Inhibitors UCB PHARMA S.A. (BE) 2010-12-02 — — US disclosed
WO-2009122148-A1 FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS PI3K KINASE INHIBITORS UCB PHARMA S.A. (BE) 2009-10-08 — — WO disclosed
WO-2009071890-A1 TRICYCLIC KINASE INHIBITORS UCB PHARMA S.A. (BE) 2009-06-11 — — WO disclosed
WO-2009071895-A1 FUSED THIAZOLE AND THIOPHENE DERIVATIVES AS KINASE INHIBITORS UCB PHARMA S.A. (BE) 2009-06-11 — — WO disclosed
EP-2029570-A1 FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS UCB Pharma S.A. (BE) 2009-03-04 — — EP disclosed
WO-2007141504-A1 FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS UCB PHARMA S.A. (BE) 2007-12-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100305066-A1 Fused Thiophene Derivatives as Kinase Inhibitors PIKFYVE, PI4KA, PIK3CA ADORA2A 3962/4885HTT 1234/4885HSD17B10 2922/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.