Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.52 |
| ▸ | PIM1 | P11309 | 4/20 | 0.51 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.51 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3756544 | 1.00 | HPGD (0.52) | HPGDAKR1B1PIM1PIM2CISD1 | |
| SCHEMBL3765524 | 0.92 | MMP3 (0.55) | NPC1RAB9APTGS2POLB | |
| SCHEMBL12997314 | 0.92 | MMP3 (0.55) | NPC1RAB9APTGS2POLB | |
| SCHEMBL3765526 | 0.92 | MMP3 (0.55) | NPC1RAB9APTGS2POLB | |
| SCHEMBL3758497 | 0.89 | ESRRA (0.58) | HPGDPIM1PIM2IGF1R | |
| SCHEMBL3754090 | 0.89 | HPGD (0.50) | HPGD | |
| SCHEMBL3758583 | 0.89 | HPGD (0.46) | HPGDAKR1B1PIM1PIM2CISD1 | |
| SCHEMBL3758581 | 0.89 | HPGD (0.46) | HPGDAKR1B1PIM1PIM2CISD1 | |
| SCHEMBL3754087 | 0.89 | HPGD (0.50) | HPGD | |
| SCHEMBL3758500 | 0.89 | ESRRA (0.58) | HPGDPIM1PIM2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305174-A1 | Novel Heterocyclic Derivatives | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2010-12-02 | — | — | US | claimed |
| US-20100305174-A1 | Novel Heterocyclic Derivatives | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2010-12-02 | — | — | US | disclosed |
| US-20100305174-A1 | Novel Heterocyclic Derivatives | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2010-12-02 | — | — | US | disclosed |
| US-20100305174-A1 | Novel Heterocyclic Derivatives | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2010-12-02 | — | — | US | disclosed |
| EP-1868990-A2 | NOVEL HETEROCYCLIC DERIVATIVES | Orchid Research Laboratories Limited (IN) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006109146-A2 | NOVEL HETEROCYCLIC DERIVATIVES | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2006-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305174-A1 | Novel Heterocyclic Derivatives | UGT1A1, CYP3A4, CYP3A43 | HPGD 228/4885AKR1B1 85/4885PIM1 1211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.