MMP3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL58793	0.36	13/20
SCHEMBL58218	0.34	13/20
Actinonin (SCHEMBL123273)	0.46	12/20
Hydrochloric Acid (SCHEMBL59932)	0.41	11/20
Hydrochloric Acid (SCHEMBL60916)	0.41	11/20
Hydrochloric Acid (SCHEMBL82688)	0.41	11/20
Prinomastat (SCHEMBL115696)	1.00	10/20
SCHEMBL58029	0.34	10/20
SCHEMBL207507	0.80	9/20
SCHEMBL57708	0.36	9/20
SCHEMBL58360	0.33	9/20
SCHEMBL58061	0.33	9/20
SCHEMBL58323	0.32	9/20
SCHEMBL89154	0.32	9/20
SCHEMBL159724	0.46	8/20
SCHEMBL57789	0.33	8/20
SCHEMBL58648	0.33	8/20
SCHEMBL88735	0.33	8/20
SCHEMBL207541	0.78	7/20
Aderbasib (SCHEMBL206421)	0.76	7/20

Clinical trials — most relevant to MMP3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Estimation of MMP-8 Levels in GCF and Serum and Its Correlation With Wound Healing and Clinical Outcomes After Coronally Advanced Flap and Subepithelial Connective Tissue Graft for Root Coverage in Recession Defects: A CLINICO-BIOCHEMICAL STUDY	PHASE4	SUSPENDED
Doxycycline In Lymphangioleiomyomatosis (LAM)	PHASE4	COMPLETED
Efficacy of Pioglitazone and Metformin on Cardiovascular Risk in Subjects With Insulin-Treated Type 2 Diabetes Mellitus.	PHASE4	COMPLETED
Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection - TREAT-CAD	PHASE3	COMPLETED
Sputum Matrix Metalloproteinases (MMP) mRNA and Montelukast	PHASE2	COMPLETED
Minocycline for Aneurysmal Subarachnoid Hemorrhage (MASH)	PHASE2	ACTIVE_NOT_RECRUITING
A Phase I Study of Oral COL-3 (NSC-683551), a Matrix Metalloproteinase Inhibitor, in Patients With Refractory Metastatic Cancer	PHASE1	COMPLETED
The Role of Matrix Metalloproteinases (MMPs) in Orthodontic Tooth Movement	PHASE1	COMPLETED
Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled Trial	nan	COMPLETED
Influence of Statins in Artery Aneurysms	nan	UNKNOWN
Apoptotic Changes in Gingiva Caused by Smoking	nan	COMPLETED
Evaluation of Dentinal Fluid for the Presence of Matrix Metalloproteinase 9 (MMP-9) in Pulpal Inflammation	nan	COMPLETED
Case-control Study on Matrix Metalloproteinase Levels in Tissue in Patients With Keloid Scar	nan	COMPLETED
Matrix Metalloproteinases After Surgery and/or Radiofrequency Ablation in Patients With Liver Metastases From Colorectal Cancer	nan	COMPLETED
Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence	nan	WITHDRAWN
Periodontal Health in Post COVID-19 Patients	nan	UNKNOWN
The Impact of Pregnancy and Pregnancy-associated Hypertension on Human Uterine Myometrial Artery Reactivity	nan	WITHDRAWN
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction	nan	COMPLETED
Evaluation of Different Serum Cartilage Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Subjects	nan	AVAILABLE
Matrix Metalloproteinase (MMP) in Heart Failure	nan	COMPLETED
Salivary Markers in Periodontal Disorders	nan	COMPLETED
The Effect of Non-surgical Periodontal Therapy Plus Doxycycline on HbA1c in Patients With Type 2 Diabetes Mellitus	nan	COMPLETED
The Effects of Sodium Fluoride and Chlorhexidine Use on Salivary IL-6 and Matrix Metalloproteinase Levels in Children With Active Caries	nan	RECRUITING
Serum COMP and MMP-3 in Knee Osteoarthritis	nan	NOT_YET_RECRUITING
Hypoxia-induced Autophagy in the Pathogenesis of MAP	nan	UNKNOWN
Association Between Matrix Metalloproteinase-2 Gene Polymorphism rs243865 and Susceptibility to Cataract Development	nan	COMPLETED
Investigation of Substrates Associated With the Recurrence of Atrial Fibrillation After PV Cryoablation	nan	COMPLETED
miRNA-452 in Patients With Preeclampsia and Its Correlation With MMP-9	nan	COMPLETED
Plasma and Scarring of Diabetic Ulcers	nan	COMPLETED
Pathology, Venous Disease, and Clinical Correlations	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a MMP3 binder may also engage these)

Protein	Name	Similarity
P07152	—	1.000	P07152 →
P28863	—	1.000	P28863 →
P57748	—	1.000	P57748 →
Q10835	—	1.000	Q10835 →
O55123	—	1.000	O55123 →
MMP1	Interstitial collagenase	1.000	landscape →
Q28397	—	1.000	Q28397 →
Q6Y4Q5	—	0.999	Q6Y4Q5 →
O18767	—	0.999	O18767 →
MMP10	Stromelysin-2	0.999	landscape →
Q9EPL5	—	0.998	Q9EPL5 →
P03957	—	0.997	P03957 →
P28862	—	0.997	P28862 →
P53690	—	0.997	P53690 →
O62806	—	0.997	O62806 →
MMP14	Matrix metalloproteinase-14	0.997	landscape →
MMP20	Matrix metalloproteinase-20	0.997	landscape →
Q95220	—	0.996	Q95220 →
P79227	—	0.996	P79227 →
P21692	—	0.996	P21692 →
Q10739	—	0.996	Q10739 →
O88766	—	0.996	O88766 →
P28053	—	0.996	P28053 →
O70138	—	0.996	O70138 →
Q63341	—	0.996	Q63341 →
O77656	—	0.995	O77656 →
P34960	—	0.995	P34960 →
P50757	—	0.995	P50757 →
P23097	—	0.995	P23097 →
Q5RES1	—	0.995	Q5RES1 →