Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARK3 | P27448 | 17/20 | 0.89 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.69 |
| ▸ | SGK1 | O00141 | 3/20 | 0.69 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.69 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.69 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.69 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.69 |
| ▸ | JAK2 | O60674 | 3/20 | 0.69 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.69 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.69 |
| ▸ | RAF1 | P04049 | 3/20 | 0.69 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.69 |
| ▸ | LCK | P06239 | 3/20 | 0.69 |
| ▸ | CSF1R | P07333 | 3/20 | 0.69 |
| ▸ | MET | P08581 | 3/20 | 0.69 |
| ▸ | HCK | P08631 | 3/20 | 0.69 |
| ▸ | PIM1 | P11309 | 3/20 | 0.69 |
| ▸ | SRC | P12931 | 3/20 | 0.69 |
| ▸ | BRAF | P15056 | 3/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12997804 | 0.94 | MARK3 (1.00) | MARK3IRAK4SGK1CHEK1MAPK13 | |
| SCHEMBL15006362 | 0.85 | MARK3 (0.82) | MARK3IRAK4SGK1CHEK1MAPK13 | |
| SCHEMBL12997801 | 0.82 | MARK3 (0.80) | MARK3IRAK4SGK1CHEK1MAPK13 | |
| SCHEMBL3769201 | 0.81 | MARK3 (1.00) | MARK3IRAK4SGK1CHEK1MAPK13 | |
| SCHEMBL3761756 | 0.81 | MARK3 (1.00) | MARK3IRAK4SGK1CHEK1MAPK13 | |
| SCHEMBL3761722 | 0.81 | MARK3 (1.00) | MARK3IRAK4SGK1CHEK1MAPK13 | |
| SCHEMBL3767636 | 0.81 | MARK3 (1.00) | MARK3IRAK4SGK1CHEK1MAPK13 | |
| SCHEMBL12997807 | 0.78 | MARK3 (0.72) | MARK3IRAK4SGK1CHEK1MAPK13 | |
| SCHEMBL3766730 | 0.78 | MARK3 (0.72) | MARK3IRAK4SGK1CHEK1MAPK13 | |
| SCHEMBL13053376 | 0.75 | MARK3 (0.73) | MARK3IRAK4SGK1CHEK1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178375-B1 | PYRAZOLOÝ1,5-A¨PYRIMIDINE DERIVATIVES | MERCK SHARP & DOHME (US) | 2014-09-24 | — | — | EP | disclosed |
| US-8461162-B2 | Pyrazolo[1,5-a]pyrimidine derivatives | MERCK SHARP & DOHME CORP. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20100305091-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | MERCK SHARP & DOHME LLC | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305091-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | MAPT, TTBK1, TTBK2 | MARK3 12/4885IRAK4 1300/4885SGK1 351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.