Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.41 |
| ▸ | FYN | P06241 | 4/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL835076 | 0.91 | FGFR1 (0.48) | FGFR1FGFR3CDK8NR4A2KDM5A | |
| SCHEMBL837206 | 0.84 | FGFR3 (0.70) | FGFR1FGFR3CDK8FYNNTRK1 | |
| SCHEMBL2347266 | 0.80 | FGFR1 (0.64) | FGFR1FGFR3NR4A2FYNNTRK1 | |
| SCHEMBL835756 | 0.79 | FGFR1 (0.48) | FGFR1FGFR3CDK8NR4A2KDM5A | |
| SCHEMBL835840 | 0.74 | FGFR3 (0.73) | FGFR1FGFR3CDK8FYNNTRK1 | |
| SCHEMBL12448288 | 0.74 | FGFR1 (0.66) | FGFR1FGFR3CDK8NR4A2FYN | |
| SCHEMBL837839 | 0.73 | FGFR1 (0.65) | FGFR1FGFR3CDK8NR4A2FYN | |
| SCHEMBL834829 | 0.73 | FGFR1 (0.70) | FGFR1FGFR3CDK8FYNNTRK1 | |
| SCHEMBL2340954 | 0.72 | FGFR3 (0.66) | FGFR1FGFR3CDK8FYNNTRK1 | |
| SCHEMBL837898 | 0.71 | CDK8 (0.55) | FGFR1FGFR3CDK8NR4A2KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183027-A1 | ORGANIC COMPOUNDS | Novartis Ag (CH) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009013335-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-01-29 | — | — | WO | disclosed |