Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 2/20 | 0.44 |
| ▸ | KMO | O15229 | 2/20 | 0.37 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.35 |
| ▸ | FEN1 | P39748 | 4/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.34 |
| ▸ | DHODH | Q02127 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3758623 | 0.86 | NPC1 (0.41) | JAK2JAK1NPC1MAPTRAB9A | |
| SCHEMBL3522253 | 0.82 | PDGFRB (0.39) | KMOJAK2JAK1RAB9AGRIN2B | |
| SCHEMBL3518631 | 0.80 | SMN1; SMN2 (0.45) | NPC1MAPTRAB9APLA2G2A | |
| SCHEMBL3537332 | 0.78 | KMO (0.45) | ALPLKMOALOX5APFEN1GRIN2B | |
| SCHEMBL3518253 | 0.74 | PDGFRB (0.39) | KMORAB9AGRIN2BPLA2G2A | |
| SCHEMBL3517937 | 0.74 | TSHR (0.37) | MAPTTSHRHTT | |
| SCHEMBL3520455 | 0.73 | EGLN3 (0.45) | ALPLKMOALOX5APFEN1 | |
| SCHEMBL3536173 | 0.73 | HPGD (0.39) | JAK2JAK1MAPTDHODH | |
| SCHEMBL3521595 | 0.71 | MAPT (0.37) | NPC1MAPTRAB9ATSHRHTT | |
| SCHEMBL3520739 | 0.70 | SMN1; SMN2 (0.46) | JAK2JAK1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305133-A1 | Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305133-A1 | Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN3, EGLN2 | ALPL 4086/4885KMO 350/4885F2RL3 2422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.