Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | PRKDC | P78527 | 1/20 | 0.52 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2276298 | 0.91 | PIK3CG (0.53) | SLC40A1PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL3757518 | 0.88 | PIK3CG (0.59) | SLC40A1PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL188577 | 0.86 | PIK3CG (0.68) | SLC40A1PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL188664 | 0.85 | SLC40A1 (0.62) | SLC40A1PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL189384 | 0.85 | PIK3CD (0.62) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL1792647 | 0.85 | SLC40A1 (0.51) | SLC40A1PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL3811843 | 0.84 | SLC40A1 (0.74) | SLC40A1PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL189569 | 0.84 | PIK3CG (0.73) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL13452220 | 0.82 | SLC40A1 (0.60) | SLC40A1PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL189238 | 0.80 | MEN1 (0.77) | SLC40A1PIK3CGPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139483-A2 | COMBINATION THERAPIES COMPRISING QUINOXALINE INHIBITORS OF PI3K-ALPHA FOR USE IN THE TREATMENT OF CANCER | Exelixis, Inc. (US) | 2010-01-06 | — | — | EP | claimed |
| WO-2008127594-A2 | COMBINATION THERAPIES COMPRISING QUINOXALINE INHIBITORS OF PI3K-ALPHA FOR USE IN THE TREATMENT OF CANCER | EXELIXIS, INC. (US) | 2008-10-23 | — | — | WO | claimed |