Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 3/20 | 0.86 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.45 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15456840 | 0.99 | AGTR2 (0.87) | AGTR2AGTR1ABCB11CYP3A4PDE3A | |
| SCHEMBL3757603 | 0.99 | AGTR2 (0.86) | AGTR2AGTR1ABCB11CYP3A4PDE3A | |
| Azilsartan Medoxomil SCHEMBL30770646 | 0.93 | AGTR2 (0.99) | AGTR2AGTR1ABCB11CYP3A4PDE3A | |
| Azilsartan Medoxomil SCHEMBL967313 | 0.93 | AGTR2 (0.99) | AGTR2AGTR1ABCB11CYP3A4PDE3A | |
| Azilsartan Medoxomil SCHEMBL29861385 | 0.93 | AGTR2 (1.00) | AGTR2AGTR1ABCB11CYP3A4PDE3A | |
| Azilsartan Medoxomil SCHEMBL683374 | 0.93 | AGTR2 (1.00) | AGTR2AGTR1ABCB11CYP3A4PDE3A | |
| Azilsartan Medoxomil SCHEMBL967309 | 0.92 | AGTR2 (0.99) | AGTR2AGTR1ABCB11CYP3A4PDE3A | |
| Azilsartan Medoxomil SCHEMBL968583 | 0.92 | AGTR2 (0.99) | AGTR2AGTR1ABCB11CYP3A4PDE3A | |
| Azilsartan Medoxomil SCHEMBL965772 | 0.92 | AGTR2 (0.99) | AGTR2AGTR1ABCB11CYP3A4PDE3A | |
| Azilsartan Medoxomil SCHEMBL965769 | 0.92 | AGTR2 (0.99) | AGTR2AGTR1ABCB11CYP3A4PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010075347-A2 | METHODS OF TREATING HYPERTENSION WITH AT LEAST ONE ANGIOTENSIN II RECEPTOR BLOCKER AND CHLORTHALIDONE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-07-01 | — | — | WO | disclosed |