Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16458941 | 0.91 | HSD17B10 (0.46) | PDE4BEPHX1HSD17B10HPGDGPR119 | |
| SCHEMBL376461 | 0.85 | USP2 (0.41) | HSD17B10MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL9937434 | 0.85 | CHRM2 (0.37) | EPHX1ALDH1A1 | |
| SCHEMBL25312339 | 0.83 | NR1H2 (0.47) | PDE4BEPHX1ALDH1A1MAPTGPR119 | |
| SCHEMBL5253414 | 0.82 | HSD17B10 (0.45) | PDE4BEPHX1HSD17B10MEN1ALDH1A1 | |
| SCHEMBL13604577 | 0.82 | HSD17B10 (0.45) | PDE4BEPHX1HSD17B10MEN1ALDH1A1 | |
| SCHEMBL3782792 | 0.82 | KLK7 (0.50) | PDE4BJAK2JAK1 | |
| SCHEMBL9965340 | 0.80 | PARP1 (0.53) | PDE4BJAK2JAK1 | |
| SCHEMBL28003378 | 0.80 | PARP1 (0.53) | PDE4BJAK2JAK1 | |
| SCHEMBL21854859 | 0.76 | NPC1 (0.41) | EPHX1HSD17B10MEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079743-B1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD (GB) | 2012-01-25 | — | — | EP | disclosed |
| EP-2079743-A1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | Chroma Therapeutics Limited (GB) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008050096-A1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-02 | — | — | WO | disclosed |