Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.37 |
| ▸ | FABP7 | O15540 | 1/20 | 0.36 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 7/20 | 0.33 |
| ▸ | TPSD1 | Q9BZJ3 | 7/20 | 0.33 |
| ▸ | TPSG1 | Q9NRR2 | 7/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL375890 | 0.85 | PDE4B (0.43) | EPHX1ALDH1A1 | |
| SCHEMBL16458941 | 0.83 | HSD17B10 (0.46) | EPHX1 | |
| SCHEMBL9937440 | 0.81 | PRSS1 (0.39) | PRSS1F2TPSAB1TPSD1TPSG1 | |
| SCHEMBL375867 | 0.79 | CHRM3 (0.35) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL1833567 | 0.76 | MMP2 (0.41) | ALDH1A1TSHR | |
| SCHEMBL376353 | 0.75 | HTR6 (0.34) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL919018 | 0.75 | AGTR2 (0.47) | AGTR2 | |
| SCHEMBL8402776 | 0.75 | AGTR2 (0.47) | AGTR2 | |
| SCHEMBL6653686 | 0.75 | AGTR2 (0.47) | AGTR2 | |
| SCHEMBL18952875 | 0.72 | POLB (0.35) | TSHRL3MBTL1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864318-A1 | 2-AMINOPYRAZINE DERIVATIVES AS CSF-1 R KINASE INHIBITORS | Chroma Therapeutics Ltd. (GB) | 2015-04-29 | — | — | EP | disclosed |
| WO-2014001802-A1 | 2-AMINOPYRAZINE DERIVATIVES AS CSF-1 R KINASE INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2014-01-03 | — | — | WO | disclosed |
| EP-2651454-A1 | IMAGING AGENTS | Chroma Therapeutics Ltd. (GB) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012080705-A1 | IMAGING AGENTS | CHROMA THERAPEUTICS LTD (GB) | 2012-06-21 | — | — | WO | disclosed |