Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 17/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 17/20 | 0.49 |
| ▸ | GRK5 | P34947 | 2/20 | 0.49 |
| ▸ | GRK2 | P25098 | 1/20 | 0.49 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | FER | P16591 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3682722 | 0.87 | IGF1R (0.46) | IGF1RMAPK8GRK5CDC7PLK4 | |
| SCHEMBL3757548 | 0.87 | MAP4K1 (0.53) | IGF1RMAPK8MAP4K1 | |
| SCHEMBL3685831 | 0.86 | IGF1R (0.44) | IGF1RMAPK8GRK5CDC7PLK4 | |
| SCHEMBL3749350 | 0.84 | IGF1R (0.50) | IGF1RMAPK8GRK5GRK2GRK1 | |
| SCHEMBL3686711 | 0.81 | IGF1R (0.50) | IGF1RMAPK8GRK5GRK2GRK1 | |
| SCHEMBL12429719 | 0.81 | IGF1R (0.72) | IGF1RMAPK8GRK5GRK2GRK1 | |
| SCHEMBL3685605 | 0.80 | IGF1R (0.47) | IGF1RMAPK8GRK5GRK2GRK1 | |
| SCHEMBL3804242 | 0.79 | IGF1R (0.62) | IGF1RMAPK8GRK5CDC7PLK4 | |
| SCHEMBL3686979 | 0.79 | IGF1R (0.64) | IGF1RMAPK8GRK5CDC7PLK4 | |
| SCHEMBL3805599 | 0.79 | IGF1R (0.64) | IGF1RMAPK8GRK5CDC7PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188292-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D]PYRIMIDIN-4-YL) AMINO]BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009020990-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D] PYRIMIDIN-4-YL) AMINO] BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |