Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 9/20 | 0.50 |
| ▸ | GRK2 | P25098 | 2/20 | 0.48 |
| ▸ | GRK5 | P34947 | 2/20 | 0.48 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.37 |
| ▸ | HTR7 | P34969 | 3/20 | 0.37 |
| ▸ | HTR2B | P41595 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3749350 | 0.88 | IGF1R (0.50) | IGF1RMAPK8GRK2GRK5GRK1 | |
| SCHEMBL3684982 | 0.87 | IGF1R (0.43) | IGF1RMAPK8GRK2GRK5GRK1 | |
| SCHEMBL3692378 | 0.86 | IGF1R (0.43) | IGF1RMAPK8GRK2GRK5GRK1 | |
| SCHEMBL3754829 | 0.82 | IGF1R (0.52) | IGF1RMAPK8GRK2GRK5GRK1 | |
| SCHEMBL3759311 | 0.81 | IGF1R (0.49) | IGF1RMAPK8GRK2GRK5GRK1 | |
| SCHEMBL3799415 | 0.80 | IGF1R (0.52) | IGF1RMAPK8GRK2GRK5GRK1 | |
| SCHEMBL12430018 | 0.79 | IGF1R (0.76) | IGF1RMAPK8GRK2GRK5GRK1 | |
| SCHEMBL2208489 | 0.79 | IGF1R (0.51) | IGF1RMAPK8GRK2GRK5GRK1 | |
| SCHEMBL3685605 | 0.79 | IGF1R (0.47) | IGF1RMAPK8GRK2GRK5GRK1 | |
| SCHEMBL3798693 | 0.77 | IGF1R (0.50) | IGF1RMAPK8GRK2GRK5GRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188292-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D]PYRIMIDIN-4-YL) AMINO]BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009020990-A1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D] PYRIMIDIN-4-YL) AMINO] BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |