Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 6/20 | 0.61 |
| ▸ | NT5E | P21589 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.51 |
| ▸ | PNP | P00491 | 3/20 | 0.51 |
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
| ▸ | HINT1 | P49773 | 1/20 | 0.48 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.47 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.47 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.47 |
| ▸ | KRAS | P01116 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12154664 | 1.00 | HPRT1 (0.61) | HPRT1NT5EPOLBFUT5PNP | |
| SCHEMBL12151598 | 1.00 | HPRT1 (0.61) | HPRT1NT5EPOLBFUT5PNP | |
| SCHEMBL12154815 | 0.89 | POLB (0.57) | HPRT1NT5EPOLBFUT5PNP | |
| SCHEMBL12151602 | 0.89 | POLB (0.57) | HPRT1NT5EPOLBFUT5PNP | |
| SCHEMBL12154654 | 0.88 | NT5E (0.51) | HPRT1NT5EPOLBFUT5PNP | |
| SCHEMBL12300885 | 0.88 | NT5E (0.51) | HPRT1NT5EPOLBFUT5PNP | |
| SCHEMBL12151597 | 0.88 | NT5E (0.50) | HPRT1NT5EPOLBFUT5PNP | |
| SCHEMBL21895683 | 0.87 | POLB (0.56) | HPRT1NT5EPOLBFUT5PNP | |
| SCHEMBL21895684 | 0.86 | NT5E (0.53) | HPRT1NT5EPOLBFUT5PNP | |
| SCHEMBL8896849 | 0.83 | POLB (0.62) | HPRT1NT5EPOLBPNPTGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842672-B2 | Phosphonate inhibitors of HCV | GILEAD SCIENCES, INC. (US) | 2010-11-30 | — | — | US | disclosed |
| US-20080107628-A1 | Polymerase inhibitors | GILEAD SCIENCES, INC. | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080107628-A1 | Polymerase inhibitors | POLR2H, POLR2E, POLR1E | HPRT1 529/4885NT5E 3704/4885POLB 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.