SCHEMBL376008

SCHEMBL376008

Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O

nearest known ligand 0.94

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RY1 P47900 7/20 0.94
P2RX1 P51575 4/20 0.94
P2RX3 P56373 4/20 0.94
P2RY2 P41231 3/20 0.94
P2RX2 Q9UBL9 2/20 0.94
SRC P12931 2/20 0.94
SMN1; SMN2 Q16637 2/20 0.94
ALDH1A1 P00352 2/20 0.94
P2RX4 Q99571 1/20 0.94
RNASEL Q05823 1/20 0.88
TRPM2 O94759 2/20 0.88
MACROD2 A1Z1Q3 1/20 0.88
SIRT6 Q8N6T7 1/20 0.88
MACROD1 Q9BQ69 1/20 0.88
TAS1R3 Q7RTX0 2/20 0.83
TAS1R1 Q7RTX1 2/20 0.83
DNPH1 O43598 1/20 0.83
PRKAB2 O43741 1/20 0.83
LDHA P00338 1/20 0.83
ADRB2 P07550 1/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9171542 1.00 P2RY1 (0.94) P2RY1P2RX1P2RX3P2RY2P2RX2
Adenosine Triphosphate SCHEMBL8979 1.00 P2RY1 (0.94) P2RY1P2RX1P2RX3P2RY2P2RX2
Adenosine Triphosphate SCHEMBL12789528 1.00 P2RY1 (0.94) P2RY1P2RX1P2RX3P2RY2P2RX2
Adenosine Triphosphate SCHEMBL6242713 1.00 P2RY1 (0.94) P2RY1P2RX1P2RX3P2RY2P2RX2
Adenosine Triphosphate SCHEMBL18784961 1.00 P2RY1 (0.94) P2RY1P2RX1P2RX3P2RY2P2RX2
Adenosine Triphosphate SCHEMBL13722152 1.00 P2RY1 (0.94) P2RY1P2RX1P2RX3P2RY2P2RX2
Adenosine Triphosphate SCHEMBL13722139 1.00 P2RY1 (0.94) P2RY1P2RX1P2RX3P2RY2P2RX2
Adenosine Triphosphate SCHEMBL2227081 1.00 P2RY1 (0.94) P2RY1P2RX1P2RX3P2RY2P2RX2
Adenosine Triphosphate SCHEMBL20550531 1.00 P2RY1 (0.94) P2RY1P2RX1P2RX3P2RY2P2RX2
Adenosine Triphosphate SCHEMBL8980 1.00 P2RY1 (0.94) P2RY1P2RX1P2RX3P2RY2P2RX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 133 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113624862-B Metabolome covering multiple metabolites, metabolic flux analysis method and kit 清华大学 2023-04-07 CN claimed
CN-113624862-A Metabolome covering multiple metabolites, metabolic flux analysis method and kit 清华大学 2021-11-09 CN claimed
US-8796003-B1 Label free kinase assays and reagents PLEXERA, LLC (US) 2014-08-05 US claimed
US-20120157328-A1 Label Free Kinase Assays and Reagents SUZHOU PUXIN LIFE SCIENCE & TECHNOLOGY., LTD. (CN) 2012-06-21 US claimed
EP-1451211-A2 COMPOSITIONS AND METHODS FOR MODULATING GUANYLYL CYCLASE SIGNALING RECEPTOR (GC-C) ACTIVITY AND FOR TREATING MENIERE'S DISEASE University of Copenhagen (DK) 2004-09-01 EP claimed
US-20040152868-A1 Compositions and methods for modulating guanylyl cyclase signaling receptor (gc-c) activity and for treating meniere's disease UNIVERSITY OF COPENHAGEN (DK) 2004-08-05 US claimed
WO-2002079235-A2 COMPOSITIONS AND METHODS FOR MODULATING GUANYLYL CYCLASE SIGNALING RECEPTOR (GC-C) ACTIVITY AND FOR TREATING MENIERE'S DISEASE UNIVERSITY OF COPENHAGEN (US) 2002-10-10 WO claimed
EP-1005327-A1 TARGETED LIPOSOMAL CONSTRUCTS FOR DIAGNOSTIC AND THERAPEUTIC USES SDG, INC. (US) 2000-06-07 EP claimed
US-6063400-A CARRIER; DIAGNOSTIC OR THERAPEUTIC AGENT AND SEQUESTERING AGENT SDG, INC. (US) 2000-05-16 US claimed
WO-1999001110-A1 TARGETED LIPOSOMAL CONSTRUCTS FOR DIAGNOSTIC AND THERAPEUTIC USES SDG, INC. (US) 1999-01-14 WO claimed
JP-59091894-A None JP disclosed
EP-4077344-B1 METHODS OF SEQUENCING BY SYNTHESIS USING A CONSECUTIVE LABELING SCHEME HOFFMANN LA ROCHE (CH) 2025-07-23 EP disclosed
CN-118834845-A Application of BTR1 protein in improving plant disease resistance or cultivating transgenic plant with disease resistance 华中农业大学 2024-10-25 CN disclosed
US-20240300968-A1 6-SUBSTITUTED NAPHTHALENE-1,3-DISULFONIC ACID DERIVATIVES AS MODULATORS OF THE EXTRACELLULAR NICOTINAMIDE PHOSPHORIBOSYL TRANSFERASE (ENAMPT) FOR THE TREATMENT OF E.G. DIABETES UNIV MANCHESTER (GB) 2024-09-12 US disclosed
US-20240209408-A1 ENGINEERED 3-O-KINASE VARIANTS AND METHODS OF USE CODEXIS, INC. (US) 2024-06-27 US disclosed
JP-S5991894-A PRODUCTION OF ADENOSINE-5'-TRIPHOSPHATE DAI ICHI SEIYAKU CO LTD 1984-05-26 JP disclosed
US-4152209-A CULTIVATING A STRAIN OF STREPTOMYCES OR STREPTOVERTICILLIUM SANRAKU-OCEAN CO., LTD. (JP) 1979-05-01 US disclosed
US-4141972-A Purine nucleoside 5'-phosphate (mono, di or tri) 3'(2')-diphosphates and processes for their preparation SANRAKU-OCEAN CO., LTD. (JP) 1979-02-27 US disclosed
US-4059487-A Purine nucleoside 5'-phosphate (mono, di or tri) 3'(2')-diphosphates and processes for their preparation SANRAKU-OCEAN CO., LTD. (JA) 1977-11-22 US disclosed
JP-S05991894-A 0001-01-01 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240300968-A1 6-SUBSTITUTED NAPHTHALENE-1,3-DISULFONIC ACID DERIVATIVES AS MODULATORS OF THE EXTRACELLULAR NICOTINAMIDE PHOSPHORIBOSYL TRANSFERASE (ENAMPT) FOR THE TREATMENT OF E.G. DIABETES NAPRT, NAMPT, NUDT1 P2RY1 87/4885P2RX1 449/4885P2RX3 783/4885
US-20040152868-A1 Compositions and methods for modulating guanylyl cyclase signaling receptor (gc-c) activity and for treating meniere's disease PDE7A, PDE6C, PDE9A P2RY1 492/4885P2RX1 730/4885P2RX3 385/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.