Sugi Predict

Sugi Predict / Compounds / SCHEMBL3761948

SCHEMBL3761948

SCHEMBL3761948

COCCOc1ccc(CNc2ncnc3c2cnn3-c2cc(C)cc(C)c2)cc1OCCOC

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 10/20 0.56
▸ LMNA P02545 7/20 0.56
▸ MEN1 O00255 3/20 0.56
▸ KMT2A Q03164 3/20 0.56
▸ L3MBTL1 Q9Y468 1/20 0.56
▸ ALDH1A1 P00352 6/20 0.56
▸ HSD17B10 Q99714 6/20 0.56
▸ HPGD P15428 5/20 0.56
▸ NPSR1 Q6W5P4 3/20 0.56
▸ SMN1; SMN2 Q16637 2/20 0.56
▸ MAPT P10636 9/20 0.55
▸ POLB P06746 2/20 0.54
▸ RAB9A P51151 5/20 0.53
▸ NPC1 O15118 3/20 0.53
▸ TSHR P16473 3/20 0.53
▸ MAPK1 P28482 2/20 0.53
▸ EGFR P00533 1/20 0.53
▸ TP53 P04637 5/20 0.52
▸ RXFP1 Q9HBX9 3/20 0.52
▸ HTT P42858 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3757355 0.92 KDM4E (0.68) KDM4ELMNAMEN1KMT2AL3MBTL1
SCHEMBL13058243 0.89 KDM4E (0.59) KDM4ELMNAMEN1KMT2AL3MBTL1
SCHEMBL3763577 0.89 MAPT (0.64) KDM4ELMNAMEN1KMT2AL3MBTL1
SCHEMBL3763448 0.88 MAPT (0.61) KDM4ELMNAMEN1KMT2AL3MBTL1
SCHEMBL3753970 0.85 KDM4E (0.55) KDM4ELMNAMEN1KMT2AL3MBTL1
SCHEMBL3751650 0.83 KDM4E (0.52) KDM4ELMNAMEN1KMT2AL3MBTL1
SCHEMBL3761917 0.83 KDM4E (0.52) KDM4ELMNAMEN1KMT2AL3MBTL1
SCHEMBL3763355 0.82 MAPT (0.78) KDM4ELMNAMEN1KMT2AL3MBTL1
SCHEMBL13058232 0.82 LMNA (0.57) KDM4ELMNAMEN1KMT2AL3MBTL1
SCHEMBL3757277 0.81 KDM4E (0.50) KDM4ELMNAMEN1KMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8349847-B2 Pyrazolo [3,4-D] pyrimidine derivatives as anti-cancer agents KONAKANCHI DURGA PRASAD (IN) 2013-01-08 — — US claimed
US-8349847-B2 Pyrazolo [3,4-D] pyrimidine derivatives as anti-cancer agents KONAKANCHI DURGA PRASAD (IN) 2013-01-08 — — US disclosed
US-8349847-B2 Pyrazolo [3,4-D] pyrimidine derivatives as anti-cancer agents KONAKANCHI DURGA PRASAD (IN) 2013-01-08 — — US disclosed
US-8349847-B2 Pyrazolo [3,4-D] pyrimidine derivatives as anti-cancer agents KONAKANCHI DURGA PRASAD (IN) 2013-01-08 — — US disclosed
US-20100298351-A1 NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS NATCO PHARMA LIMITED (IN) 2010-11-25 — — US disclosed
US-20100298351-A1 NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS NATCO PHARMA LIMITED (IN) 2010-11-25 — — US disclosed
US-20100298351-A1 NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS NATCO PHARMA LIMITED (IN) 2010-11-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100298351-A1 NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS DPYD, TYMP, TYMS KDM4E 1866/4885LMNA 4335/4885MEN1 2856/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.