Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 2/20 | 0.38 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.36 |
| ▸ | MTOR | P42345 | 3/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3762316 | 0.93 | LRRK2 (0.41) | HSD17B10LMNACYP3A4CYP2D6TSHR | |
| SCHEMBL16161825 | 0.90 | JAK2 (0.41) | LMNALRRK2ATRATRIPALDH1A1 | |
| SCHEMBL3764769 | 0.90 | LMNA (0.34) | HSD17B10LMNACYP3A4CYP2D6TSHR | |
| SCHEMBL3757686 | 0.90 | LMNA (0.34) | HSD17B10LMNACYP3A4CYP2D6TSHR | |
| SCHEMBL3760600 | 0.89 | HDAC1 (0.40) | ALDH1A1PIK3CAPIK3R1MTORTGFBR1 | |
| SCHEMBL16161713 | 0.88 | PIK3CD (0.38) | HSD17B10ALDH1A1CYP1A2PIK3CAPIK3CD | |
| SCHEMBL3759201 | 0.88 | PIK3CD (0.39) | LRRK2ALDH1A1PIK3CAPIK3CDPIK3CB | |
| SCHEMBL3756092 | 0.88 | ATR (0.33) | HSD17B10LMNACYP3A4CYP2D6TSHR | |
| SCHEMBL3758765 | 0.87 | PIK3CA (0.40) | HSD17B10LMNALRRK2ALDH1A1PIK3CA | |
| SCHEMBL3762353 | 0.87 | PIK3CD (0.39) | TSHRPIK3CAPIK3R1MTORPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029570-B1 | FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA SA (BE) | 2014-10-15 | — | — | EP | disclosed |
| US-8324204-B2 | Fused thiophene derivatives as kinase inhibitors | UCB PHARMA SA (BE) | 2012-12-04 | — | — | US | disclosed |
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | PIKFYVE, PI4KA, PIK3CA | HSD17B10 2922/4885LMNA 4870/4885CYP3A4 1613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.