Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.47 |
| ▸ | CTSS | P25774 | 5/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL375864 | 1.00 | CTSK (0.47) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL376032 | 1.00 | CTSK (0.47) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL4215161 | 1.00 | CTSK (0.47) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL1147462 | 0.85 | CTSK (0.48) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL11151475 | 0.85 | CTSK (0.48) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL490640 | 0.85 | CTSK (0.48) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL3777346 | 0.84 | CTSK (0.46) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL375995 | 0.84 | CTSK (0.47) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL8689950 | 0.84 | CTSK (0.50) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL1486213 | 0.84 | CTSK (0.50) | CTSKCTSSHDAC4HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079743-B1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD (GB) | 2012-01-25 | — | — | EP | disclosed |
| CN-101171039-A | Enzyme and receptor modulation | CHROMA THERAPEUTICS LTD (GB) | 2008-04-30 | — | — | CN | disclosed |