Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.70 |
| ▸ | EGFR | P00533 | 4/20 | 0.64 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.62 |
| ▸ | AURKA | O14965 | 2/20 | 0.60 |
| ▸ | INSR | P06213 | 2/20 | 0.60 |
| ▸ | IGF1R | P08069 | 2/20 | 0.60 |
| ▸ | ROS1 | P08922 | 2/20 | 0.60 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.60 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | STK25 | O00506 | 1/20 | 0.60 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.60 |
| ▸ | CASK | O14936 | 1/20 | 0.60 |
| ▸ | GAK | O14976 | 1/20 | 0.60 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.60 |
| ▸ | MUSK | O15146 | 1/20 | 0.60 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.60 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.60 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3761718 | 0.93 | PLK1 (0.60) | ALKEGFRZAP70AURKAINSR | |
| SCHEMBL18843489 | 0.86 | ZAP70 (0.82) | ALKEGFRZAP70AURKAINSR | |
| SCHEMBL3766664 | 0.84 | PLK1 (0.60) | ALKEGFRZAP70AURKAINSR | |
| SCHEMBL3771264 | 0.83 | PLK1 (0.63) | ALKEGFRAURKAINSRIGF1R | |
| SCHEMBL18843601 | 0.83 | ALK (0.85) | ALKEGFRZAP70AURKAINSR | |
| SCHEMBL18843510 | 0.82 | ALK (0.92) | ALKEGFRZAP70AURKAINSR | |
| SCHEMBL18843517 | 0.82 | ALK (1.00) | ALKEGFRZAP70AURKAINSR | |
| SCHEMBL12729778 | 0.81 | ALK (0.81) | ALKEGFRZAP70AURKAINSR | |
| SCHEMBL20805541 | 0.81 | ZAP70 (0.80) | ALKEGFRZAP70AURKAINSR | |
| SCHEMBL3761696 | 0.80 | PLK1 (0.59) | ALKEGFRAURKAINSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435422-B1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBVIE INC (US) | 2014-12-17 | — | — | EP | claimed |
| US-8486933-B2 | Pyrimidine inhibitors of kinase activity | ABBVIE INC. (US) | 2013-07-16 | — | — | US | claimed |
| WO-2010138578-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | claimed |
| US-20100305112-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | US | claimed |
| EP-2435422-B1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBVIE INC (US) | 2014-12-17 | — | — | EP | disclosed |
| US-8486933-B2 | Pyrimidine inhibitors of kinase activity | ABBVIE INC. (US) | 2013-07-16 | — | — | US | disclosed |
| WO-2010138578-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |
| US-20100305112-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305112-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | IGF1R, TK1, CDK2 | ALK 397/4885EGFR 120/4885ZAP70 684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.