Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 9/20 | 0.69 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.69 |
| ▸ | KIT | P10721 | 1/20 | 0.69 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.63 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.63 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.63 |
| ▸ | CLK1 | P49759 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.59 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.59 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | IGF1R | P08069 | 1/20 | 0.59 |
| ▸ | PLCG1 | P19174 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL723792 | 0.90 | MAP3K11 (0.71) | MAP3K11NTRK1KITDYRK1ADYRK2 | |
| SCHEMBL17397340 | 0.88 | PLCG1 (0.74) | MAP3K11PLCG1 | |
| SCHEMBL3768119 | 0.85 | RIPK1 (0.81) | NTRK1KITDYRK1ADYRK2DYRK1B | |
| SCHEMBL4160145 | 0.84 | NTRK1 (0.77) | NTRK1KITDYRK1ADYRK2DYRK1B | |
| SCHEMBL3763379 | 0.84 | NTRK1 (0.80) | NTRK1KITDYRK1ADYRK2DYRK1B | |
| SCHEMBL17319204 | 0.84 | NTRK1 (0.80) | NTRK1KITDYRK1ADYRK2DYRK1B | |
| SCHEMBL723789 | 0.83 | MAP3K11 (1.00) | MAP3K11NTRK1KITDYRK1ADYRK2 | |
| SCHEMBL4167572 | 0.83 | NTRK1 (0.79) | NTRK1KITDYRK1ADYRK2DYRK1B | |
| SCHEMBL12763251 | 0.83 | MAP3K11 (0.80) | MAP3K11NTRK1KITDYRK1ADYRK2 | |
| SCHEMBL3766005 | 0.82 | NTRK1 (0.77) | NTRK1KITDYRK1ADYRK2DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | GlaxoSmithKline, LLC | 2012-09-20 | — | — | US | claimed |
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | GLAXOSMITHKLINE LLC | 2009-09-17 | — | — | US | claimed |
| WO-2021006707-A1 | USE OF SGK1 INHIBITOR AS THERAPEUTIC AGENT FOR INFLAMMATORY NEUROLOGICAL DISEASES | 한양대학교 산학협력단 | 2021-01-14 | — | — | WO | disclosed |
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | GlaxoSmithKline, LLC | 2012-09-20 | — | — | US | disclosed |
| WO-2010049173-A1 | USE OF INHIBITORS OF HOST KINASES FOR THE TREATMENT OF INFECTIOUS DISEASES | CENIX BIOSCIENCE GMBH (DE) | 2010-05-06 | — | — | WO | disclosed |
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | GLAXOSMITHKLINE LLC | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | SGK1, SGK2, SGK3 | MAP3K11 56/4885NTRK1 964/4885KIT 1364/4885 |
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | SGK1, SGK2, SGK3 | MAP3K11 48/4885NTRK1 997/4885KIT 1240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.