Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 12/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
| ▸ | GRK2 | P25098 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18192934 | 1.00 | BACE1 (0.35) | BACE1BACE2GRK2CASP6CASP8 | |
| SCHEMBL18192834 | 1.00 | BACE1 (0.35) | BACE1BACE2GRK2CASP6CASP8 | |
| SCHEMBL18192887 | 0.97 | GRK2 (0.36) | BACE1BACE2GRK2CASP6CASP8 | |
| SCHEMBL18192906 | 0.97 | GRK2 (0.36) | BACE1BACE2GRK2CASP6CASP8 | |
| SCHEMBL18192943 | 0.87 | BACE1 (0.39) | BACE1BACE2ALDH1A1 | |
| SCHEMBL949522 | 0.85 | USP30 (0.36) | BACE1BACE2 | |
| SCHEMBL968545 | 0.85 | ALDH1A1 (0.34) | BACE1BACE2ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL968863 | 0.85 | ALDH1A1 (0.34) | BACE1BACE2ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL2931790 | 0.84 | BACE1 (0.39) | BACE1BACE2 | |
| SCHEMBL2928303 | 0.84 | BACE1 (0.39) | BACE1BACE2CTSDAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451793-B1 | BACE INHIBITORS | LILLY CO ELI (US) | 2016-11-02 | — | — | EP | disclosed |
| US-8278441-B2 | BACE inhibitors | ELI LILLY AND COMPANY (US) | 2012-10-02 | — | — | US | disclosed |
| EP-2451793-A1 | BACE INHIBITORS | Eli Lilly and Company (US) | 2012-05-16 | — | — | EP | disclosed |