Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.69 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31627592 | 0.82 | P2RX7 (1.00) | P2RX7GRM4GSK3AGSK3BABL1 | |
| SCHEMBL3650483 | 0.82 | P2RX7 (0.67) | P2RX7GRM4GSK3AGSK3BABL1 | |
| SCHEMBL107554 | 0.82 | P2RX7 (1.00) | P2RX7GRM4GSK3AGSK3BABL1 | |
| SCHEMBL13726856 | 0.80 | GRM4 (0.66) | P2RX7GRM4 | |
| Hydrochloric Acid SCHEMBL30402220 | 0.80 | P2RX7 (0.65) | P2RX7GRM4GSK3AGSK3BABL1 | |
| SCHEMBL1224735 | 0.78 | — | — | |
| SCHEMBL30822602 | 0.78 | — | — | |
| SCHEMBL28171086 | 0.78 | P2RX7 (0.61) | P2RX7GRM4GSK3AGSK3BABL1 | |
| SCHEMBL4611244 | 0.77 | P2RX7 (0.61) | P2RX7GRM4GSK3AGSK3BABL1 | |
| SCHEMBL13728642 | 0.77 | GRM4 (0.62) | P2RX7GRM4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106535891-A | Histone deacetylase inhibitors, compositions and methods of use thereof | CHDI基金会股份有限公司 | 2017-03-22 | — | — | CN | claimed |
| US-20230056785-A1 | GAS-STORING MATERIAL INCLUDING METAL/ORGANIC FRAMEWORK BONDED BY HYDROXAMIC ACID | RIKKYO EDUCATIONAL CORPORATION (JP) | 2023-02-23 | — | — | US | disclosed |
| US-8153630-B2 | of Aurora-2 (Aurora-A) protein kinase; anticancer; 6-(pyrazolylamino)-4-pyrimidine carboxamides; Methyl 2-(4-cyclopropanecarboxamidophenylsulfanyl)-5-amino-6-(5-methylpyrazol-3-ylamino)-4-pyrimidinecarboxylate | MIIKANA THERAPEUTICS, INC. (US) | 2012-04-10 | — | — | US | disclosed |
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |
| EP-1812424-A4 | KINASE INHIBITORS | MIIKANA THERAPEUTICS INC (US) | 2009-07-08 | — | — | EP | disclosed |
| US-20080200485-A1 | Kinase Inhibitors | MIIKANA THERAPEUTICS, INC. | 2008-08-21 | — | — | US | disclosed |
| EP-1812424-A2 | KINASE INHIBITORS | Miikana Therapeutics, Inc. (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006055831-A2 | KINASE INHIBITORS | MIIKANA THERAPEUTICS, INC. (US) | 2006-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200485-A1 | Kinase Inhibitors | AURKC, AURKA, AURKB | P2RX7 4288/4885GRM4 4842/4885HDAC1 1154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.