Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | STK17B | O94768 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.34 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.33 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.33 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3756048 | 0.92 | KDM4E (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGATR | |
| SCHEMBL3752119 | 0.91 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGSTK17B | |
| SCHEMBL16161738 | 0.91 | HDAC1 (0.38) | KDM1AHDAC1JMJD6PIK3CDPIK3CA | |
| SCHEMBL3761788 | 0.90 | HTR7 (0.41) | KDM1AHDAC1JMJD6PIK3CDPIK3CA | |
| SCHEMBL3760006 | 0.89 | PRKDC (0.39) | KDM1AHDAC1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3754939 | 0.88 | KDM1A (0.39) | KDM1AHDAC1JMJD6PIK3CDPIK3CA | |
| SCHEMBL3765884 | 0.87 | PRKDC (0.41) | KDM1AHDAC1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3760314 | 0.87 | PIK3CD (0.42) | PIK3CDPIK3CAPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL3764670 | 0.86 | PIK3CA (0.43) | PIK3CDPIK3CAPIK3CBPIK3CGJAK2 | |
| SCHEMBL16161804 | 0.86 | ATR (0.40) | PIK3CDPIK3CAPIK3CBPIK3CGATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029570-B1 | FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA SA (BE) | 2014-10-15 | — | — | EP | disclosed |
| US-8324204-B2 | Fused thiophene derivatives as kinase inhibitors | UCB PHARMA SA (BE) | 2012-12-04 | — | — | US | disclosed |
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | PIKFYVE, PI4KA, PIK3CA | KDM1A 3543/4885HDAC1 669/4885JMJD6 3134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.