⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7159626 | 0.77 | — | — | |
| SCHEMBL21590897 | 0.72 | — | — | |
| SCHEMBL20456725 | 0.71 | HTR6 (0.34) | — | |
| SCHEMBL1190286 | 0.71 | HTR6 (0.34) | — | |
| SCHEMBL22524926 | 0.69 | — | — | |
| SCHEMBL3810430 | 0.68 | HTR6 (0.44) | — | |
| SCHEMBL4977845 | 0.67 | HTR6 (0.38) | — | |
| SCHEMBL17748322 | 0.65 | — | — | |
| SCHEMBL18692324 | 0.65 | — | — | |
| SCHEMBL9687115 | 0.65 | HPGD (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520320-B1 | Tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3'-pyrrolidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same | DAINIPPON PHARMACEUTICAL CO (JP) | 1997-09-10 | — | — | EP | claimed |
| EP-0520320-A2 | Tetrahydropyrrolo 1,2-a pyrazine-4-spiro-3'-pyrrolidine derivatives, processes for the preparation thereof and pharaceutical compositions containing the same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1992-12-30 | — | — | EP | claimed |
| US-12600728-B2 | Interleukin-17 inhibitors | NOVARTIS AG (CH) | 2026-04-14 | — | — | US | disclosed |
| US-12559462-B2 | Pyrimidine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2026-02-24 | — | — | US | disclosed |
| US-20250270172-A1 | Pyrimidine Derivatives As Modulators of the 5-HT2A Serotonin Receptor Useful For The Treatment of Disorders Related Thereto | ARENA PHARMACEUTICALS, INC. (US) | 2025-08-28 | — | — | US | disclosed |
| US-20250122225-A1 | MASP-2 INHIBITORS AND METHODS OF USE | OMEROS CORPORATION (US) | 2025-04-17 | — | — | US | disclosed |
| US-20230391782-A1 | INTERLEUKIN-17 INHIBITORS | NOVARTIS AG (CH) | 2023-12-07 | — | — | US | disclosed |
| US-8435978-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2013-05-07 | — | — | US | disclosed |
| US-20100324009-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2010-12-23 | — | — | US | disclosed |
| US-20100317644-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2010-12-16 | — | — | US | disclosed |
| EP-2148673-A1 | CINNAMIDE COMPOUNDS FOR DEMENTIA | Eisai R&D Management Co., Ltd. (JP) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008139984-A1 | CINNAMIDE COMPOUNDS FOR DEMENTIA | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-11-20 | — | — | WO | disclosed |
| US-20080153843-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2008-06-26 | — | — | US | disclosed |
| EP-0520320-B1 | Tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3'-pyrrolidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same | DAINIPPON PHARMACEUTICAL CO (JP) | 1997-09-10 | — | — | EP | disclosed |
| US-5378846-A | Anxiolytic agents | RUSSIAN-AMERICAN INSTITUTE FOR NEW DRUG DEVELOPMENT (US) | 1995-01-03 | — | — | US | disclosed |
| WO-1994029315-A1 | 1,2,3,4-TETRAHYDROPYRROLO[1,2-a]PYRAZINES | THE RUSSIAN-AMERICAN INSTITUTE FOR NEW DRUG DEVELOPMENT (US) | 1994-12-22 | — | — | WO | disclosed |
| US-5258382-A | Antidiabetic agents or reductase inhibitors | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1993-11-02 | — | — | US | disclosed |
| EP-0520320-A2 | Tetrahydropyrrolo 1,2-a pyrazine-4-spiro-3'-pyrrolidine derivatives, processes for the preparation thereof and pharaceutical compositions containing the same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1992-12-30 | — | — | EP | disclosed |