Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nalbuphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 11/20 | 1.00 |
| ▸ | OPRK1 known ✓ | P41145 | 10/20 | 1.00 |
| ▸ | OPRD1 known ✓ | P41143 | 9/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nalbuphine SCHEMBL6123677 | 1.00 | OPRM1 (1.00) | OPRM1OPRK1OPRD1LMNACYP1A2 | |
| Nalbuphine SCHEMBL12646324 | 1.00 | OPRM1 (1.00) | OPRM1OPRK1OPRD1LMNACYP1A2 | |
| Nalbuphine SCHEMBL722708 | 1.00 | OPRM1 (1.00) | OPRM1OPRK1OPRD1LMNACYP1A2 | |
| Nalbuphine SCHEMBL13906700 | 1.00 | OPRM1 (1.00) | OPRM1OPRK1OPRD1LMNACYP1A2 | |
| Nalbuphine SCHEMBL12588894 | 1.00 | OPRM1 (1.00) | OPRM1OPRK1OPRD1LMNACYP1A2 | |
| Nalbuphine SCHEMBL13906701 | 1.00 | OPRM1 (1.00) | OPRM1OPRK1OPRD1LMNACYP1A2 | |
| Nalbuphine SCHEMBL19767567 | 1.00 | OPRM1 (1.00) | OPRM1OPRK1OPRD1LMNACYP1A2 | |
| Nalbuphine SCHEMBL18458094 | 1.00 | OPRM1 (1.00) | OPRM1OPRK1OPRD1LMNACYP1A2 | |
| Nalbuphine SCHEMBL19385893 | 1.00 | OPRM1 (1.00) | OPRM1OPRK1OPRD1LMNACYP1A2 | |
| Nalbuphine SCHEMBL21090866 | 1.00 | OPRM1 (1.00) | OPRM1OPRK1OPRD1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 24352 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122087518-A | Method for classifying anesthetic drugs by using neural network | — | 2026-05-26 | — | — | CN | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| US-12594388-B2 | Device to deliver a predetermined amount of a substance to a natural orifice of the body | APTARGROUP, INC. (US) | 2026-04-07 | — | — | US | claimed |
| US-12569478-B2 | Sequestration compounds for treatment of substance use disorder and uses thereof | CLEAR SCIENTIFIC, INC. (US) | 2026-03-10 | — | — | US | claimed |
| US-12564597-B2 | Ibogaine analogs as therapeutics for neurological and psychiatric disorders | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE OF NEW YORK (US) | 2026-03-03 | — | — | US | claimed |
| US-20260021090-A1 | METHODS OF ADMINISTERING NALBUPHINE | TREVI THERAPEUTICS INC (US) | 2026-01-22 | — | — | US | claimed |
| EP-4100010-B1 | NITROXIDE COMPOUNDS FOR USE IN THE TREATMENT OF OPIOID-INDUCED RESPIRATORY DEPRESSION (OIRD) | UNIV CASE WESTERN RESERVE (US) | 2026-01-07 | — | — | EP | claimed |
| US-12508259-B2 | Pharmaceutical formulations containing Nalbuphine | HUMANWELL PHARMACEUTICAL US, Inc. (US) | 2025-12-30 | — | — | US | claimed |
| EP-4665315-A1 | METHODS OF PREPARATION OF ZINGERONE, COMPOSITIONS COMPRISING ZINGERONE, AND USES THEREFOR | Evithe Limited (NZ) | 2025-12-24 | — | — | EP | claimed |
| EP-4665758-A1 | TREATMENT OF OPIOD-INDUCED PAIN | H. Lundbeck A/S (DK) | 2025-12-24 | — | — | EP | claimed |
| EP-0024690-B1 | ANALGESIC MIXTURE OF NALBUPHINE AND ACETYLSALICYLIC ACID, DERIVATIVE OR SALT THEREOF | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-07-20 | — | — | EP | claimed |
| EP-0074105-A1 | Nalbuphine-narcotic oral analgesic composition and method of producing analgesia | Magruder, Michael Richard (US) | 1983-03-16 | — | — | EP | claimed |
| US-4369172-A | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose | FOREST LABORATORIES INC. (US) | 1983-01-18 | — | — | US | claimed |
| EP-0019282-B1 | ANALGESIC MIXTURE OF NALBUPHINE AND ACETAMINOPHEN | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-01-12 | — | — | EP | claimed |
| US-4366159-A | Nalbuphine-narcotic analgesic composition and method of producing analgesia | Magruder, Michael Richard (US) | 1982-12-28 | — | — | US | claimed |
| US-4282215-A | Analgesic mixture of nalbuphine and acetylsalicylic acid, derivative or salt thereof | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-08-04 | — | — | US | claimed |
| EP-0024690-A1 | Analgesic mixture of nalbuphine and acetylsalicylic acid, derivative or salt thereof | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-03-11 | — | — | EP | claimed |
| WO-1981000409-A1 | INTERMEDIATE COMPOUNDS FOR PREPARATION OF MORPHINE DERIVATIVES | MALLINCKRODT INC (US) | 1981-02-19 | — | — | WO | claimed |
| US-4237140-A | SYNERGISTIC | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-12-02 | — | — | US | claimed |
| EP-0019282-A1 | Analgesic mixture of nalbuphine and acetaminophen | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-11-26 | — | — | EP | claimed |