Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.39 |
| ▸ | ADK | P55263 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3766006 | 0.90 | PIK3CA (0.43) | PIK3CAPIK3CDPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL3754750 | 0.86 | HTR1A (0.38) | PIK3CAPIK3CDPIK3CBPIK3CGBUB1 | |
| SCHEMBL3762227 | 0.82 | PIK3CA (0.39) | PIK3CAPIK3CDPIK3CBPIK3CGKDM4E | |
| SCHEMBL3760142 | 0.81 | PIK3CA (0.45) | PRKDCPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3764482 | 0.79 | BUB1 (0.44) | PIK3CAPIK3CDPIK3CBPIK3CGKDM4E | |
| SCHEMBL3761577 | 0.78 | PRKDC (0.42) | PRKDCPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3757579 | 0.78 | PIK3CD (0.37) | PIK3CAPIK3CDPIK3CBPIK3CGTDP1 | |
| SCHEMBL3762759 | 0.78 | PRKDC (0.40) | PRKDCPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3766682 | 0.78 | KDM1A (0.40) | PIK3CAPIK3CDPIK3CBPIK3CGBUB1 | |
| SCHEMBL3762158 | 0.78 | LRRK2 (0.38) | PIK3CAPIK3CDPIK3CBPIK3CGKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029570-B1 | FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA SA (BE) | 2014-10-15 | — | — | EP | disclosed |
| US-8324204-B2 | Fused thiophene derivatives as kinase inhibitors | UCB PHARMA SA (BE) | 2012-12-04 | — | — | US | disclosed |
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2010-12-02 | — | — | US | disclosed |
| EP-2029570-A1 | FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma S.A. (BE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007141504-A1 | FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2007-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | PIKFYVE, PI4KA, PIK3CA | PRKDC 112/4885PIK3CA 3/4885PIK3CD 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.