Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 1.00 |
| ▸ | RAB9A | P51151 | 8/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.82 |
| ▸ | GAA | P10253 | 2/20 | 0.82 |
| ▸ | MAPT | P10636 | 6/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.77 |
| ▸ | GLA | P06280 | 1/20 | 0.77 |
| ▸ | USP2 | O75604 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27943648 | 0.87 | NPC1 (0.76) | NPC1RAB9ASMN1; SMN2GAAMAPT | |
| SCHEMBL27953824 | 0.85 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2GAAMAPT | |
| SCHEMBL5928915 | 0.84 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2GAAMAPT | |
| SCHEMBL5928772 | 0.78 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2GAAMAPT | |
| SCHEMBL3714715 | 0.78 | SMN1; SMN2 (0.71) | NPC1RAB9ASMN1; SMN2GAAMAPT | |
| SCHEMBL14743414 | 0.77 | SMN1; SMN2 (0.69) | NPC1RAB9ASMN1; SMN2GAAMAPT | |
| SCHEMBL28308020 | 0.77 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2GAAKMT2A | |
| SCHEMBL28308019 | 0.76 | SMN1; SMN2 (0.81) | NPC1RAB9ASMN1; SMN2GAAMAPT | |
| SCHEMBL28677827 | 0.75 | SMN1; SMN2 (0.62) | NPC1RAB9ASMN1; SMN2GAAMAPT | |
| SCHEMBL3709037 | 0.75 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962639-B2 | Potassium channel modulators | ABBVIE INC. (US) | 2015-02-24 | — | — | US | disclosed |
| US-20100305109-A1 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305109-A1 | POTASSIUM CHANNEL MODULATORS | KCNQ1, KCNQ2, KCNJ2 | NPC1 377/4885RAB9A 1488/4885SMN1; SMN2 1516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.