Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | NCF1 | P14598 | 5/20 | 0.37 |
| ▸ | CYBB | P04839 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL264202 | 0.92 | MCHR1 (0.36) | MCHR1CYP11B1CYP11B2NCF1CYBB | |
| SCHEMBL23665203 | 0.86 | MCHR1 (0.50) | MCHR1CYP11B1CYP11B2NCF1CYBB | |
| SCHEMBL263965 | 0.86 | MCHR1 (0.43) | MCHR1NCF1 | |
| SCHEMBL21223549 | 0.83 | MCHR1 (0.42) | MCHR1BACE1CHRNA7FYNSYK | |
| SCHEMBL21222941 | 0.79 | NCF1 (0.42) | MCHR1NCF1CYBB | |
| SCHEMBL263783 | 0.78 | MCHR1 (0.48) | MCHR1NCF1CYBBBACE1 | |
| SCHEMBL21223595 | 0.76 | MCHR1 (0.47) | MCHR1BACE1HASPINCHRNA7JAK2 | |
| SCHEMBL21223293 | 0.73 | MCHR1 (0.57) | MCHR1NCF1 | |
| SCHEMBL23665199 | 0.70 | MCHR1 (0.48) | MCHR1NCF1CYBBBACE1 | |
| SCHEMBL21223516 | 0.69 | MCHR1 (0.46) | MCHR1BACE1HASPINCHRNA7JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183241-A2 | 2-PYRIDINE CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | Pfizer Limited (GB) | 2010-05-12 | — | — | EP | disclosed |
| WO-2008135826-A2 | 2 -PYRIDINE CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | PFIZER LIMITED (GB) | 2008-11-13 | — | — | WO | disclosed |