Diethyl Hydrogen Phosphate — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA2A ADRA2B ADRA2C ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CALCR CHRNA3 CHRNB4 ESR1 ESR2 GHSR GNRHR GSC1 HSPA8 MALT1 MC1R MC4R NOS1 NOS2 NOS3 OPRK1 OXTR RAMP1 RAMP2 RAMP3 SCN5A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 dacA dacB dacC folP ftsI mrcA mrcB mrdA rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Diethyl Hydrogen Phosphate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

	gene	UniProt	supporting neighbours	confidence
▸	TSHR	P16473	3/20	0.46

▸	PPARD	Q03181	2/20	0.44

▸	TP53	P04637	1/20	0.42

▸	TDP1	Q9NUW8	1/20	0.42

▸	CA12	O43570	1/20	0.39

▸	CA1	P00915	1/20	0.39

▸	CA2	P00918	1/20	0.39

▸	CA9	Q16790	1/20	0.39

▸	ALDH1A1	P00352	1/20	0.38

▸	LMNA	P02545	1/20	0.38

▸	HSD17B10	Q99714	1/20	0.38

▸	FFAR3	O14843	1/20	0.37

▸	LCK	P06239	1/20	0.37

▸	FYN	P06241	1/20	0.37

▸	MVD	P53602	1/20	0.36

▸	POLB	P06746	1/20	0.35

▸	MAPT	P10636	1/20	0.35

▸	MAPK1	P28482	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Diethyl Hydrogen Phosphate SCHEMBL28596733	0.97	TSHR (0.43)	TSHRPPARDTP53TDP1CA12
Diethyl Hydrogen Phosphate SCHEMBL31065172	0.92	TSHR (0.48)	TSHRPPARDTP53TDP1CA12
Acetic Acid SCHEMBL28479624	0.89	PPARD (0.38)	TSHRPPARDCA12CA1CA2
Diethyl Hydrogen Phosphate SCHEMBL27873282	0.89	PPARD (0.38)	TSHRPPARDTP53TDP1CA12
Diethyl Hydrogen Phosphate SCHEMBL27294237	0.89	TSHR (0.56)	TSHRPPARDTP53TDP1CA12
Diethyl Hydrogen Phosphate SCHEMBL93056	0.89	—	—
Diethyl Hydrogen Phosphate SCHEMBL27873286	0.87	TSHR (0.43)	TSHRPPARDTP53TDP1CA12
Diethyl Hydrogen Phosphate SCHEMBL697968	0.86	PPARD (0.39)	TSHRPPARDTP53TDP1CA12
Diethyl Hydrogen Phosphate SCHEMBL906759	0.86	TSHR (0.53)	TSHRPPARDTP53TDP1CA12
Diethyl Hydrogen Phosphate SCHEMBL8431810	0.86	TSHR (0.53)	TSHRPPARDTP53TDP1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-122025690-A	Composite modified material of high-toughness graphite bipolar plate and preparation method thereof	青岛高等密封制品有限公司	2026-05-12	—	—	CN	disclosed
WO-2022088573-A1	METHOD FOR PREPARING PYROTINIB	苏州富士莱医药股份有限公司	2022-05-05	—	—	WO	disclosed
CN-112358467-B	Preparation process of pyrroltinib	苏州富士莱医药股份有限公司	2021-07-30	—	—	CN	disclosed
CN-112279838-B	Preparation method of pyrroltinib	苏州富士莱医药股份有限公司	2021-07-13	—	—	CN	disclosed
CN-112358467-A	Preparation process of pyrroltinib	苏州富士莱医药股份有限公司	2021-02-12	—	—	CN	disclosed
CN-112279838-A	Preparation method of pyrroltinib	苏州富士莱医药股份有限公司	2021-01-29	—	—	CN	disclosed
CN-105884831-A	Preparation method of phorate pesticide hapten and application of phorate pesticide hapten	江苏师范大学	2016-08-24	—	—	CN	disclosed
CN-102448458-B	Methods and compositions for treating flaviviridae virus infections	UNIV LELAND STANFORD JUNIOR	2015-07-22	—	—	CN	disclosed
US-8975247-B2	Methods and compositions of treating a flaviviridae family viral infection	THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNION UNIVERSITY (US)	2015-03-10	—	—	US	disclosed
EP-2699096-A2	METHOD FOR MOSQUITO CONTROL	Dobson, Stephen (US)	2014-02-26	—	—	EP	disclosed
US-20120276050-A1	METHODS AND COMPOSITIONS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION	NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT	2012-11-01	—	—	US	disclosed
WO-2012145145-A2	METHOD FOR MOSQUITO CONTROL	DOBSON STEPHEN (US)	2012-10-26	—	—	WO	disclosed
CN-102448458-A	Methods and compositions for treating flaviviridae virus infections	UNIV LELAND STANFORD JUNIOR	2012-05-09	—	—	CN	disclosed
EP-2408449-A2	METHODS AND COMPOSITIONS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION	The Board Of Trustees Of The University Of the Leland Stanford Junior University (US)	2012-01-25	—	—	EP	disclosed
WO-2010107739-A2	METHODS AND COMPOSITIONS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION	THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US)	2010-09-23	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20120276050-A1	METHODS AND COMPOSITIONS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION	NSUN3, RNGTT, NSUN2	TSHR 4438/4885PPARD 2491/4885TP53 4482/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.