Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 16/20 | 0.67 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | S100A4 | P26447 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5029623 | 0.84 | PTGDR2 (0.48) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL27970100 | 0.81 | PTGDR2 (0.72) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL13206681 | 0.81 | PTGDR2 (0.86) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL1056786 | 0.81 | PTGDR2 (0.46) | PTGDR2AKR1B1CYP2C9S100A4 | |
| Azd1981 SCHEMBL30538014 | 0.80 | PTGDR2 (1.00) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| Azd1981 SCHEMBL1053662 | 0.80 | PTGDR2 (1.00) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL5029669 | 0.80 | PTGDR2 (0.45) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL904388 | 0.79 | PTGDR2 (0.79) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL1053997 | 0.77 | PTGDR2 (0.67) | PTGDR2AKR1B1CYP2C9S100A4SLC6A4 | |
| SCHEMBL1194103 | 0.74 | AKR1B1 (0.55) | PTGDR2AKR1B1CYP2C9S100A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102482214-A | Intermediates and processes for preparing 4- (acetylamino) -3- [ (4-chloro-phenyl) thio ] -2-methyl-1H-indole-1-acetic acid | ASTRAZENECA AB | 2012-05-30 | — | — | CN | disclosed |
| EP-2451780-A1 | INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF 4- (ACETYLAMINO) ) -3- [ (4-CHLORO-PHENYL) THIO]-2-METHYL-1H-INDOLE-1-ACETIC ACID | AstraZeneca AB (SE) | 2012-05-16 | — | — | EP | disclosed |
| EP-1844012-A2 | NOVEL PROCESS FOR THE PREPARATION OF SUBSTITUTED INDOLES | AstraZeneca AB (SE) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006075139-A2 | NOVEL PROCESS FOR THE PREPARATION OF SUBSTITUTED INDOLES | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |