Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3762865 | 0.82 | POLB (0.61) | ALDH1A1KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL3773835 | 0.81 | ME2 (0.55) | ALDH1A1MAPTKMT2AMEN1KDM4E | |
| SCHEMBL3768285 | 0.81 | NOTUM (0.47) | ALDH1A1MAPTKMT2AMEN1TSHR | |
| SCHEMBL3765450 | 0.80 | NOTUM (0.50) | ALDH1A1MAPTKMT2AMEN1TSHR | |
| SCHEMBL3773978 | 0.80 | POLB (0.60) | ALDH1A1KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL3763137 | 0.79 | ME2 (0.55) | ALDH1A1MAPTKMT2AMEN1KDM4E | |
| SCHEMBL3766241 | 0.79 | NOTUM (0.47) | ALDH1A1MAPTKMT2AMEN1TSHR | |
| SCHEMBL3769985 | 0.79 | POLB (0.59) | ALDH1A1KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL5550621 | 0.78 | NPSR1 (0.45) | ALDH1A1MAPTKMT2AMEN1TSHR | |
| SCHEMBL3777307 | 0.78 | ME2 (0.52) | ALDH1A1MAPTKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851474-B2 | Dipiperazinyl ketones and related analogues | NEUROGEN CORPORATION (US) | 2010-12-14 | — | — | US | disclosed |