Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 10/20 | 0.65 |
| ▸ | KYAT3 | Q6YP21 | 4/20 | 0.65 |
| ▸ | KYAT1 | Q16773 | 3/20 | 0.65 |
| ▸ | GOT1 | P17174 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RHOA | P61586 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16613003 | 0.86 | AADAT (0.67) | AADATKYAT3KYAT1GOT1 | |
| SCHEMBL6763354 | 0.83 | AADAT (0.71) | AADATKYAT3KYAT1GOT1 | |
| SCHEMBL3775216 | 0.82 | AADAT (0.64) | AADATKYAT3KYAT1GOT1 | |
| SCHEMBL3781828 | 0.81 | AADAT (0.65) | AADATKYAT3KYAT1GOT1 | |
| SCHEMBL3773884 | 0.80 | AADAT (0.63) | AADATKYAT3KYAT1GOT1RAB9A | |
| SCHEMBL2143232 | 0.80 | AADAT (1.00) | AADATKYAT3KYAT1GOT1 | |
| SCHEMBL3780456 | 0.79 | AADAT (0.61) | AADATKYAT3KYAT1GOT1 | |
| SCHEMBL3776633 | 0.78 | AADAT (0.64) | AADATKYAT3KYAT1GOT1 | |
| SCHEMBL3772535 | 0.78 | AADAT (0.64) | AADATKYAT3KYAT1GOT1 | |
| SCHEMBL16613060 | 0.78 | AADAT (0.60) | AADATKYAT3KYAT1GOT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183238-B2 | Bicyclic and tricyclic compounds as KAT II inhibitors | PFIZER INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-20100324043-A1 | Bicyclic And Tricyclic Compounds As KAT II Inhibitors | PFIZER INC | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324043-A1 | Bicyclic And Tricyclic Compounds As KAT II Inhibitors | KAT2A, KAT2B, KAT6B | AADAT 2284/4885KYAT3 129/4885KYAT1 69/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.