Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2947875 | 0.91 | USP2 (0.54) | USP2KDM4ECHEK1BCL2L1MGLL | |
| SCHEMBL10222720 | 0.84 | MGLL (0.46) | USP2KDM4EMGLLALDH1A1HPGD | |
| SCHEMBL10222721 | 0.84 | MGLL (0.43) | USP2KDM4EMGLLALDH1A1HPGD | |
| SCHEMBL377181 | 0.84 | CHRNA7 (0.55) | USP2CHEK1MGLLALDH1A1MEN1 | |
| SCHEMBL2951912 | 0.84 | KDM4E (0.64) | USP2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2952332 | 0.83 | USP2 (0.54) | USP2KDM4ECHEK1BCL2L1ALDH1A1 | |
| SCHEMBL2946610 | 0.83 | USP2 (0.54) | USP2KDM4ECHEK1BCL2L1ALDH1A1 | |
| SCHEMBL23610369 | 0.82 | KDM4E (0.71) | USP2KDM4ECHEK1ALDH1A1HPGD | |
| SCHEMBL17737082 | 0.82 | KDM4E (0.71) | USP2KDM4ECHEK1ALDH1A1HPGD | |
| SCHEMBL1664911 | 0.82 | KDM4E (0.57) | USP2KDM4ECHEK1MGLLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11390610-B2 | Piperazine derivatives as MAGL inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2022-07-19 | — | — | US | disclosed |
| EP-3694840-B1 | PIPERAZINE DERIVATIVES AS MAGL INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-08-04 | — | — | EP | disclosed |
| US-20200299277-A1 | PIPERAZINE DERIVATIVES AS MAGL INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2020-09-24 | — | — | US | disclosed |
| US-8524947-B2 | Acylsulfonamides and processes for producing the same | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-09-03 | — | — | US | disclosed |
| US-8524947-B2 | Acylsulfonamides and processes for producing the same | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-09-03 | — | — | US | disclosed |
| US-20130203709-A1 | ACYLSULFONAMIDES AND PROCESSES FOR PRODUCING THE SAME | THE PENN STATE RESEARCH FOUNDATION (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130203709-A1 | ACYLSULFONAMIDES AND PROCESSES FOR PRODUCING THE SAME | THE PENN STATE RESEARCH FOUNDATION (US) | 2013-08-08 | — | — | US | disclosed |
| EP-1888543-B1 | APOPTOSIS PROMOTERS | ABBOTT LAB (US) | 2012-08-01 | — | — | EP | disclosed |
| WO-2012021486-A2 | ACYLSULFONAMIDES AND PROCESSES FOR PRODUCING THE SAME | UNIVERSITY OF SOUTH FLORIDA (US) | 2012-02-16 | — | — | WO | disclosed |
| EP-1765778-B1 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LAB (US) | 2012-01-25 | — | — | EP | disclosed |
| EP-1888543-A1 | APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2008-02-20 | — | — | EP | disclosed |
| EP-1765778-A2 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006127364-A1 | APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2006-11-30 | — | — | WO | disclosed |
| EP-1318978-B1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LAB (US) | 2006-02-08 | — | — | EP | disclosed |
| WO-2005117543-A2 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2005-12-15 | — | — | WO | disclosed |
| US-20050272744-A1 | N-sulfonylcarboximidamide apoptosis promoters | ABBVIE INC. | 2005-12-08 | — | — | US | disclosed |
| US-20040192681-A1 | N-acylsulfonamide apoptosis promoters | ABBVIE INC. | 2004-09-30 | — | — | US | disclosed |
| US-6720338-B2 | BCL-X1 INHIBITING COMPOSITIONS AND METHODS OF PROMOTING APOPTOSIS IN A MAMMAL | ABBOTT LABORATORIES | 2004-04-13 | — | — | US | disclosed |
| US-20020086887-A1 | N-Acylsulfonamide apoptosis promoters | ABBVIE INC. | 2002-07-04 | — | — | US | disclosed |
| US-20020055631-A1 | N-acylsulfonamide apoptosis promoters | ABBOTT LABORATORIES | 2002-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020086887-A1 | N-Acylsulfonamide apoptosis promoters | BAX, BCLAF1, BCL2 | USP2 1839/4885KDM4E 1911/4885CHEK1 3294/4885 |
| US-20020055631-A1 | N-acylsulfonamide apoptosis promoters | BAX, BCLAF1, BCL2 | USP2 1819/4885KDM4E 1563/4885CHEK1 3163/4885 |
| US-20040192681-A1 | N-acylsulfonamide apoptosis promoters | BAX, BCLAF1, BCL2 | USP2 1839/4885KDM4E 1911/4885CHEK1 3294/4885 |
| US-11390610-B2 | Piperazine derivatives as MAGL inhibitors | MAGI3, PYM1, MAG | USP2 2552/4885KDM4E 2009/4885CHEK1 4362/4885 |
| US-20200299277-A1 | PIPERAZINE DERIVATIVES AS MAGL INHIBITORS | MAGI3, PYM1, MAG | USP2 2552/4885KDM4E 2009/4885CHEK1 4362/4885 |
| US-20050272744-A1 | N-sulfonylcarboximidamide apoptosis promoters | BAX, BCL2, BAD | USP2 1129/4885KDM4E 1408/4885CHEK1 1071/4885 |
| US-20130203709-A1 | ACYLSULFONAMIDES AND PROCESSES FOR PRODUCING THE SAME | BCL2, BCL2L2, BCL6 | USP2 162/4885KDM4E 2852/4885CHEK1 3401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.