Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.47 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PLEC | Q15149 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38098 | 0.88 | PDE5A (0.56) | MAPTKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3491664 | 0.85 | RNASEH1 (0.58) | MAPTKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL46037 | 0.85 | MAPT (0.50) | MAPTKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL21504938 | 0.84 | KMT2A (0.58) | MAPTKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL38376 | 0.84 | RNASEH1 (0.52) | MAPTKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3492896 | 0.84 | RNASEH1 (0.57) | MAPTKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3492895 | 0.83 | RNASEH1 (0.51) | MAPTKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL4514505 | 0.81 | KMT2A (0.65) | MAPTKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL38887 | 0.80 | RNASEH1 (0.49) | MAPTKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3494842 | 0.78 | MAPT (0.58) | MAPTKDM4EALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |