Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 8/20 | 0.53 |
| ▸ | LTB4R2 | Q9NPC1 | 8/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3239000 | 0.93 | LTB4R (0.51) | LTB4RLTB4R2FOLH1TRPM8MCL1 | |
| SCHEMBL3768292 | 0.90 | FOLH1 (0.51) | LTB4RLTB4R2FOLH1MCL1ALOX5 | |
| SCHEMBL3764722 | 0.87 | HPGD (0.55) | LTB4RLTB4R2FOLH1MCL1ALDH1A1 | |
| SCHEMBL6969974 | 0.83 | LTB4R (0.47) | LTB4RLTB4R2TRPM8MCL1ALOX5 | |
| SCHEMBL3766462 | 0.82 | LTB4R (0.46) | LTB4RLTB4R2TRPM8KDM4EALDH1A1 | |
| SCHEMBL6968160 | 0.79 | TSHR (0.48) | LTB4RLTB4R2FOLH1MCL1ALDH1A1 | |
| SCHEMBL27788715 | 0.79 | LTB4R (0.57) | LTB4RLTB4R2FOLH1TRPM8POLB | |
| SCHEMBL646469 | 0.79 | FOLH1 (0.45) | LTB4RLTB4R2FOLH1TRPM8MCL1 | |
| SCHEMBL19326705 | 0.78 | MAOB (0.60) | FOLH1MCL1KDM4EALDH1A1POLB | |
| SCHEMBL24983867 | 0.78 | FOLH1 (0.65) | FOLH1MCL1KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2181092-B1 | 1,3-DIHYDROISOINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-01-14 | — | — | EP | disclosed |
| US-20100311745-A1 | 1,3-DIHYDROISOINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311745-A1 | 1,3-DIHYDROISOINDOLE DERIVATIVES | HSP90AB1, HSP90AA1, HSP90AB2P | LTB4R 3784/4885LTB4R2 3539/4885FOLH1 4204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.