Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 15/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 14/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3522 | 0.84 | MAPK1 (0.41) | SLC6A4SLC6A2MAPK1CACNA2D1 | |
| SCHEMBL2526 | 0.83 | HTT (0.44) | SLC6A4 | |
| SCHEMBL3449 | 0.80 | SLC6A2 (0.62) | SLC6A4SLC6A2CACNA2D1 | |
| SCHEMBL9747 | 0.79 | SLC6A4 (0.61) | SLC6A4SLC6A2MAPK1 | |
| SCHEMBL3732 | 0.79 | SLC6A4 (0.63) | SLC6A4SLC6A2CACNA2D1 | |
| Oxalic Acid SCHEMBL3770 | 0.78 | SLC6A4 (0.69) | SLC6A4SLC6A2CACNA2D1 | |
| SCHEMBL3336 | 0.77 | SLC6A2 (0.61) | SLC6A4SLC6A2CACNA2D1 | |
| SCHEMBL2014600 | 0.77 | SLC6A2 (0.61) | SLC6A4SLC6A2CACNA2D1 | |
| Hydrochloric Acid SCHEMBL7771743 | 0.76 | SLC6A4 (0.73) | SLC6A4SLC6A2CACNA2D1 | |
| Oxalic Acid SCHEMBL3521 | 0.74 | CACNA2D1 (0.52) | SLC6A4SLC6A2MAPK1CACNA2D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0273658-A1 | 3-Aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |