Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 14/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3771559 | 1.00 | JAK2 (0.53) | JAK2NTRK1HRH3 | |
| SCHEMBL30010557 | 1.00 | JAK2 (0.53) | JAK2NTRK1HRH3 | |
| SCHEMBL4105087 | 0.77 | JAK2 (0.50) | JAK2NTRK1 | |
| SCHEMBL22382687 | 0.76 | JAK2 (0.50) | JAK2NTRK1 | |
| SCHEMBL4106164 | 0.74 | JAK2 (0.50) | JAK2NTRK1HRH3 | |
| SCHEMBL932823 | 0.70 | NTRK1 (0.88) | JAK2NTRK1 | |
| SCHEMBL932821 | 0.70 | NTRK1 (0.88) | JAK2NTRK1 | |
| SCHEMBL948131 | 0.70 | JAK2 (0.46) | JAK2NTRK1 | |
| SCHEMBL949026 | 0.69 | NTRK1 (0.48) | JAK2NTRK1 | |
| SCHEMBL2693603 | 0.69 | NTRK1 (1.00) | JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110003214-B | Substituted pyrazolo [1,5-a ] pyrimidine compounds as TRK kinase inhibitors | 阵列生物制药公司 | 2021-12-21 | — | — | CN | disclosed |
| EP-2451812-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |