Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ALDH1A2 | O94788 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4105087 | 0.86 | JAK2 (0.50) | JAK2NTRK1 | |
| SCHEMBL4106164 | 0.83 | JAK2 (0.50) | JAK2NTRK1 | |
| SCHEMBL4293207 | 0.82 | JAK2 (0.53) | JAK2NTRK1 | |
| SCHEMBL3771555 | 0.76 | JAK2 (0.53) | JAK2NTRK1 | |
| SCHEMBL30010557 | 0.76 | JAK2 (0.53) | JAK2NTRK1 | |
| SCHEMBL3771559 | 0.76 | JAK2 (0.53) | JAK2NTRK1 | |
| SCHEMBL4301490 | 0.75 | JAK2 (0.56) | JAK2NTRK1 | |
| SCHEMBL20340606 | 0.75 | KDM4E (0.38) | DRD2 | |
| SCHEMBL20015853 | 0.72 | CHRNB2 (0.42) | — | |
| SCHEMBL16474295 | 0.72 | RIPK1 (0.34) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10758542-B2 | Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2020-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10758542-B2 | Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors | LTK, TXK, FRK | JAK2 133/4885NTRK1 7/4885DRD2 3220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.