SCHEMBL3772666

SCHEMBL3772666

CCOC(=O)c1oc(-c2ccc(C(F)(F)F)cc2)nc1C

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.55
KDM4E B2RXH2 1/20 0.55
MEN1 O00255 1/20 0.55
HSP90AA1 P07900 1/20 0.55
CRHBP P24387 1/20 0.55
KMT2A Q03164 1/20 0.55
CRHR2 Q13324 1/20 0.55
PPARD Q03181 6/20 0.55
ALDH1A1 P00352 1/20 0.52
LMNA P02545 1/20 0.52
PPARG P37231 4/20 0.52
TARBP2 Q15633 6/20 0.49
IKBKB O14920 1/20 0.49
PPARA Q07869 3/20 0.48
PTPN1 P18031 1/20 0.47
PDCD4 Q53EL6 1/20 0.46
HDAC4 P56524 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4467472 0.87 ALDH1A1 (0.69) MAPTKDM4EMEN1HSP90AA1CRHBP
SCHEMBL3764200 0.85 KDM4E (0.51) MAPTKDM4EMEN1HSP90AA1CRHBP
SCHEMBL4464787 0.85 MAPT (0.51) MAPTKDM4EMEN1HSP90AA1CRHBP
SCHEMBL4473430 0.85 PPARD (0.55) MAPTKDM4EMEN1HSP90AA1CRHBP
SCHEMBL22658100 0.84 ESR2 (0.58) KDM4EKMT2AALDH1A1LMNATARBP2
SCHEMBL5999578 0.83 MAPT (0.49) MAPTKDM4EMEN1HSP90AA1CRHBP
SCHEMBL23574516 0.83 TARBP2 (0.67) MAPTKDM4EMEN1KMT2AALDH1A1
SCHEMBL10709187 0.83 ALDH1A1 (0.75) MAPTKDM4EKMT2AALDH1A1LMNA
SCHEMBL3764083 0.83 KDM4E (0.48) MAPTKDM4EMEN1HSP90AA1CRHBP
SCHEMBL4739626 0.82 IKBKB (0.58) MAPTKDM4EPPARDALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1934206-B1 PHENYL- AND PYRIDYL-I, 2 , 4 -OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS SANOFI SA (FR) 2011-12-14 EP disclosed
EP-1934206-B1 PHENYL- AND PYRIDYL-I, 2 , 4 -OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS SANOFI SA (FR) 2011-12-14 EP disclosed
US-7851493-B2 Phenyl-1,2,4-oxadiazolone derivatives with phenyl group, processes for their preparation and their use as pharmaceuticals SANOFI-AVENTIS (FR) 2010-12-14 US disclosed
US-7851493-B2 Phenyl-1,2,4-oxadiazolone derivatives with phenyl group, processes for their preparation and their use as pharmaceuticals SANOFI-AVENTIS (FR) 2010-12-14 US disclosed
US-7851493-B2 Phenyl-1,2,4-oxadiazolone derivatives with phenyl group, processes for their preparation and their use as pharmaceuticals SANOFI-AVENTIS (FR) 2010-12-14 US disclosed
US-20090281084-A1 PHENYL-1,2,4-OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS SANOFI-AVENTIS (FR) 2009-11-12 US disclosed
US-20090281084-A1 PHENYL-1,2,4-OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS SANOFI-AVENTIS (FR) 2009-11-12 US disclosed
US-20090281084-A1 PHENYL-1,2,4-OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS SANOFI-AVENTIS (FR) 2009-11-12 US disclosed
US-20080287409-A1 PHENYL AND PYRIDINYL-1,2,4-OXADIAZOLONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS SANOFI-AVENTIS (FR) 2008-11-20 US disclosed
US-20080287409-A1 PHENYL AND PYRIDINYL-1,2,4-OXADIAZOLONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS SANOFI-AVENTIS (FR) 2008-11-20 US disclosed
US-20080287409-A1 PHENYL AND PYRIDINYL-1,2,4-OXADIAZOLONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS SANOFI-AVENTIS (FR) 2008-11-20 US disclosed
EP-1934206-A1 PHENYL- AND PYRIDYL-I, 2 , 4 -OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS Sanofi-Aventis (FR) 2008-06-25 EP disclosed
WO-2007039172-A1 PHENYL- AND PYRIDYL-I, 2 , 4 -OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS SANOFI-AVENTIS (DE) 2007-04-12 WO disclosed
WO-2007039172-A1 PHENYL- AND PYRIDYL-I, 2 , 4 -OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS SANOFI-AVENTIS (DE) 2007-04-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080287409-A1 PHENYL AND PYRIDINYL-1,2,4-OXADIAZOLONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS PPARD, PPARA, PPARG MAPT 2006/4885KDM4E 2433/4885MEN1 4437/4885
US-20090281084-A1 PHENYL-1,2,4-OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS PPARD, PPARA, PPARG MAPT 1066/4885KDM4E 2892/4885MEN1 4631/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.