Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.40 |
| ▸ | FEN1 | P39748 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3009558 | 0.95 | MEN1 (0.49) | ALDH1A1SMN1; SMN2L3MBTL1MAPTLMNA | |
| SCHEMBL3011114 | 0.94 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2L3MBTL1MAPTLMNA | |
| SCHEMBL3012132 | 0.92 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2L3MBTL1MAPTLMNA | |
| SCHEMBL3003681 | 0.89 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2L3MBTL1MAPTLMNA | |
| SCHEMBL3007795 | 0.86 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2L3MBTL1MAPTLMNA | |
| SCHEMBL3013011 | 0.86 | SMN1; SMN2 (0.54) | ALDH1A1SMN1; SMN2L3MBTL1MAPTLMNA | |
| SCHEMBL3011631 | 0.86 | AR (0.54) | ALDH1A1SMN1; SMN2L3MBTL1MAPTLMNA | |
| SCHEMBL3011536 | 0.85 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2L3MBTL1MAPTLMNA | |
| SCHEMBL3652767 | 0.85 | KMT2A (0.53) | ALDH1A1SMN1; SMN2L3MBTL1MAPTLMNA | |
| SCHEMBL3012064 | 0.84 | MEN1 (0.51) | ALDH1A1SMN1; SMN2L3MBTL1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |