Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2619901 | 1.00 | EPHX1 (0.39) | EPHX1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2108331 | 1.00 | EPHX1 (0.39) | EPHX1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2631696 | 1.00 | EPHX1 (0.39) | EPHX1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL18032972 | 0.90 | BACE1 (0.36) | EPHX1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2108797 | 0.90 | EPHX1 (0.41) | EPHX1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2108798 | 0.90 | EPHX1 (0.41) | EPHX1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8034193 | 0.90 | EPHX1 (0.41) | EPHX1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL11293044 | 0.89 | EPHX1 (0.42) | EPHX1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL3773247 | 0.88 | EPHX1 (0.37) | EPHX1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2632297 | 0.88 | EPHX1 (0.37) | EPHX1SMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317850-A1 | CONDENSED AMINODIHYDROTHIAZINE DERIVATIVE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317850-A1 | CONDENSED AMINODIHYDROTHIAZINE DERIVATIVE | BACE1, APP, BACE2 | EPHX1 2197/4885SMN1; SMN2 857/4885ALDH1A1 2468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.