Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | PPID | Q08752 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ARG2 | P78540 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15105972 | 0.79 | MEN1 (0.46) | MEN1KMT2ASMN1; SMN2MAPTTSHR | |
| SCHEMBL9578561 | 0.79 | MAOB (0.46) | MAOBMAPTTSHRTP53ALDH1A1 | |
| SCHEMBL6067639 | 0.78 | MEN1 (0.62) | MEN1KMT2ASMN1; SMN2MAPTTSHR | |
| SCHEMBL351793 | 0.77 | MEN1 (0.51) | MEN1KMT2ASMN1; SMN2MAPTTSHR | |
| SCHEMBL9059077 | 0.77 | SLC6A2 (0.44) | MAOB | |
| SCHEMBL17018866 | 0.75 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2MAPTTSHR | |
| SCHEMBL1295249 | 0.75 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2MAPTTSHR | |
| SCHEMBL1295244 | 0.75 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2MAPTTSHR | |
| SCHEMBL3918527 | 0.75 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2MAPTTSHR | |
| Phenylacetaldehyde SCHEMBL28519985 | 0.73 | SMN1; SMN2 (0.49) | MEN1KMT2ASMN1; SMN2MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101896492-B | Tetriacyclodipyranyl coumarins and the anti-HIV and anti-tuberculosis uses thereof | INST OF MATARIA MEDICA CHINESE | 2015-05-06 | — | — | CN | disclosed |
| EP-2216335-B1 | TETRACYCLODIPYRANYL COUMARINS AND THE ANTI-HIV AND ANTI-TUBERCULOSIS USES THEREOF | INST MATERIA MEDICA CAMS (CN) | 2014-03-12 | — | — | EP | disclosed |
| CN-101100470-B | Tetracyclic bispyranyl coumarin compounds | INST MATERIA MEDICA CAMS | 2013-02-13 | — | — | CN | disclosed |
| US-20100324067-A1 | TETRACYCLIC DIPYRANO-COUMARIN COMPOUNDS WITH ANTI-HIV AND ANTI-MYCOBACTERIUM TUBERCULOSIS ACTIVITIES | INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2010-12-23 | — | — | US | disclosed |
| CN-101896492-A | Tetriacyclodipyranyl coumarins and the anti-HIV and anti-tuberculosis uses thereof | INST OF MATARIA MEDICA CHINESE | 2010-11-24 | — | — | CN | disclosed |
| EP-2216335-A1 | TETRIACYCLODIPYRANYL COUMARINS AND THE ANTI-HIV AND ANTI-TUBERCULOSIS USES THEREOF | Institute of Mataria Medica, Chinese Academy of Medical Sciences (CN) | 2010-08-11 | — | — | EP | disclosed |
| CN-101100470-A | Tetracyclic bispyranyl coumarin compounds | INST MATERIA MEDICA CAMS (CN) | 2008-01-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324067-A1 | TETRACYCLIC DIPYRANO-COUMARIN COMPOUNDS WITH ANTI-HIV AND ANTI-MYCOBACTERIUM TUBERCULOSIS ACTIVITIES | TBCB, TBC1D15, TBC1D5 | MAOB 2995/4885MEN1 2795/4885KMT2A 4759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.