Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Racemethionine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.55 |
| ▸ | BHMT | Q93088 | 10/20 | 0.52 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.52 |
| ▸ | NOS2 | P35228 | 3/20 | 0.47 |
| ▸ | NOS3 | P29474 | 2/20 | 0.47 |
| ▸ | NOS1 | P29475 | 2/20 | 0.47 |
| ▸ | GRM8 | O00222 | 1/20 | 0.45 |
| ▸ | GRM6 | O15303 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GSR | P00390 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.45 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methionine SCHEMBL377910 | 1.00 | RNPEP (0.55) | RNPEPBHMTBHMT2NOS2NOS3 | |
| Racemethionine SCHEMBL29275085 | 0.98 | RNPEP (0.57) | RNPEPBHMTBHMT2NOS2NOS3 | |
| Racemethionine SCHEMBL29275088 | 0.98 | RNPEP (0.57) | RNPEPBHMTBHMT2NOS2NOS3 | |
| Methionine SCHEMBL38922 | 0.98 | RNPEP (0.57) | RNPEPBHMTBHMT2NOS2NOS3 | |
| Racemethionine SCHEMBL29275087 | 0.98 | RNPEP (0.57) | RNPEPBHMTBHMT2NOS2NOS3 | |
| Racemethionine SCHEMBL29275086 | 0.98 | RNPEP (0.57) | RNPEPBHMTBHMT2NOS2NOS3 | |
| Racemethionine SCHEMBL38923 | 0.98 | RNPEP (0.57) | RNPEPBHMTBHMT2NOS2NOS3 | |
| Racemethionine SCHEMBL3970073 | 0.98 | RNPEP (0.57) | RNPEPBHMTBHMT2NOS2NOS3 | |
| Racemethionine SCHEMBL10879097 | 0.96 | RNPEP (0.55) | RNPEPBHMTBHMT2NOS2NOS3 | |
| Methionine SCHEMBL8388172 | 0.96 | RNPEP (0.55) | RNPEPBHMTBHMT2NOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408759-A1 | PROCESSES FOR PREPARING AMINO-SUBSTITUTED GAMMA-LACTAMS | Valorisation-Recherche, Société en Commandite (CA) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010105367-A1 | PROCESSES FOR PREPARING AMINO-SUBSTITUTED GAMMA-LACTAMS | VALORISATION-RECHERCHE SOCIETE EN COMMANDITE (CA) | 2010-09-23 | — | — | WO | disclosed |
| US-4680283-A | LACHRYMATORS | MERCK & CO., INC. (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0176436-A2 | Analogs of substance P and eledoisin | MERCK & CO. INC. (US) | 1986-04-02 | — | — | EP | disclosed |