Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6885396 | 0.78 | MAPT (0.38) | NPSR1HPGDLMNACYP3A4ALDH1A1 | |
| SCHEMBL8557965 | 0.76 | NPSR1 (0.37) | NPSR1HPGDKDM4EMAPK1L3MBTL1 | |
| SCHEMBL31333069 | 0.67 | CHRM3 (0.40) | NPSR1LMNAKDM4EALDH1A1TSHR | |
| SCHEMBL19297097 | 0.62 | NPSR1 (0.34) | NPSR1KDM4EMAPK1ALDH1A1TSHR | |
| SCHEMBL9242569 | 0.61 | NPSR1 (0.46) | NPSR1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL7311210 | 0.61 | NPSR1 (0.33) | NPSR1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL9292998 | 0.60 | NPSR1 (0.41) | NPSR1LMNAKDM4EMAPK1L3MBTL1 | |
| SCHEMBL5798986 | 0.58 | — | — | |
| SCHEMBL22570267 | 0.58 | — | — | |
| SCHEMBL5344290 | 0.58 | CHRM3 (0.39) | NPSR1HPGDLMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2187893-A2 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | Anacor Pharmaceuticals, Inc. (US) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009111676-A2 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS, INC (US) | 2009-09-11 | — | — | WO | disclosed |