SCHEMBL9242569

SCHEMBL9242569

COC(=O)C1=C(C(=O)OC)C(=O)C(C(=O)OC)=C(C(=O)OC)C1=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.46
FGFR1 P11362 4/20 0.44
FGFR2 P21802 4/20 0.44
FGFR4 P22455 4/20 0.44
FGFR3 P22607 4/20 0.44
SRC P12931 3/20 0.44
ALDH1A1 P00352 3/20 0.41
TSHR P16473 3/20 0.40
CA1 P00915 4/20 0.39
CA2 P00918 4/20 0.39
CA12 O43570 3/20 0.39
CA7 P43166 3/20 0.39
CA9 Q16790 3/20 0.39
CA14 Q9ULX7 3/20 0.39
MAPT P10636 2/20 0.39
KMT2A Q03164 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
HSD17B10 Q99714 1/20 0.39
POLB P06746 2/20 0.38
MEN1 O00255 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9655522 0.78 FGFR1 (0.39) NPSR1FGFR1FGFR2FGFR4FGFR3
SCHEMBL21234787 0.78 FGFR1 (0.39) NPSR1FGFR1FGFR2FGFR4FGFR3
SCHEMBL9063074 0.75 NPSR1 (0.46) NPSR1ALDH1A1TSHRCA1CA2
SCHEMBL11720920 0.73 FGFR1 (0.75) NPSR1FGFR1FGFR2FGFR4FGFR3
SCHEMBL10260335 0.69 CA1 (0.57) NPSR1ALDH1A1TSHRCA1CA2
SCHEMBL2992529 0.69 NPSR1 (0.40) NPSR1FGFR1FGFR2FGFR4FGFR3
SCHEMBL9626490 0.69 ALDH1A1 (0.49) NPSR1ALDH1A1TSHRCA1CA2
SCHEMBL14000244 0.67 TSHR (0.39) NPSR1FGFR1FGFR2FGFR4FGFR3
SCHEMBL7126586 0.67 NPSR1 (0.39) NPSR1FGFR1FGFR2FGFR4FGFR3
SCHEMBL9653199 0.66 ALDH1A1 (0.52) ALDH1A1TSHRMAPTTDP1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5446011-A Imagewise coloring when heating; mixture of n-substituted indole, aromatic polyhydroxy compound, carbonyl compound and an acid RICOH COMPANY, LTD. (JP) 1995-08-29 US disclosed
US-5130291-A HEAT-SENSITIVE RECORDING PAPER OSAKA SEALING PRINTING CO., LTD. (JP) 1992-07-14 US disclosed
EP-0133182-B1 OXIDATION-REDUCTION COLOR PRODUCTION-TYPE HEAT-SENSITIVE RECORDING UNIT MITSUI TOATSU CHEMICALS, Inc. (JP) 1989-03-15 EP disclosed
EP-0055847-B1 PRESSURE SENSITIVE RECORDING UNIT MITSUI TOATSU CHEMICALS, Inc. (JP) 1986-04-02 EP disclosed
US-4561000-A METHINE-TYPE CHROMOGEN, BENZOQUINONE OXIDIZER, COLOR PRODUCTION SENSITIVITY REGULATOR, SUBSTRATE MITSUI TOATSU CHEMICALS, INC. (JP) 1985-12-24 US disclosed
EP-0133182-A1 OXIDATION-REDUCTION COLOR PRODUCTION-TYPE HEAT-SENSITIVE RECORDING UNIT MITSUI TOATSU CHEMICALS, Inc. (JP) 1985-02-20 EP disclosed
US-4398753-A METHINE-TYPE DYES AND QUINONE DERIVATIVE IN REDOX SYSTEM FOR CARBON-FREE REPRODUCTION MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1983-08-16 US disclosed
EP-0055847-A1 Pressure sensitive recording unit MITSUI TOATSU CHEMICALS, Inc. (JP) 1982-07-14 EP disclosed