Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL1291555 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL42945 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL22686437 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL29587574 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL23012792 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL21555662 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL227913 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL20668544 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL216857 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL1231819 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1552 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250345482-A1 | 3D PRINTED GALLIUM SCAFFOLD | NORTHEAST OHIO MEDICAL UNIV (US) | 2025-11-13 | — | — | US | claimed |
| CN-119542445-A | Topological chiral half-metal catalyst for oxygen electrocatalysis and preparation method and application thereof | 中国科学院宁波材料技术与工程研究所 | 2025-02-28 | — | — | CN | claimed |
| WO-2024137849-A1 | GALLIUM-LOADED HYDROGELS FOR BONE TREATMENT | NORTHEAST OHIO MEDICAL UNIVERSITY (US) | 2024-06-27 | — | — | WO | claimed |
| CN-117257955-B | Application of ferredoxin reductase Fpr as target point of pseudomonas aeruginosa treatment drug | 深圳大学 | 2024-03-15 | — | — | CN | claimed |
| CN-117410484-A | Composite lithium anode material and preparation method and application thereof | 中国科学院大学 | 2024-01-16 | — | — | CN | claimed |
| CN-117257955-A | Application of ferredoxin reductase Fpr as target point of pseudomonas aeruginosa treatment drug | 深圳大学 | 2023-12-22 | — | — | CN | claimed |
| CN-116435588-A | Ion-doped modified lithium zirconium silicon phosphorus oxide solid electrolyte and preparation and application thereof | 湖州南木纳米科技有限公司 | 2023-07-14 | — | — | CN | claimed |
| CN-115650280-A | Preparation method of gallium salt | 昆明理工大学 | 2023-01-31 | — | — | CN | claimed |
| CN-114601031-A | Feed additive, feed and preparation method thereof | 深圳龙宫伊莱特生物科技有限公司 | 2022-06-10 | — | — | CN | claimed |
| US-11213530-B2 | Gallium in the treatment of coronavirus disease | BERNSTEIN LAWRENCE RICHARD (US) | 2022-01-04 | — | — | US | claimed |
| EP-0463126-A4 | METHODS OF ENHANCING WOUND HEALING AND TISSUE REPAIR | — | 1993-03-24 | — | — | EP | claimed |
| US-5175006-A | Method of treating arthritis using gallium compounds | THE OHIO STATE UNIVERSITY (US) | 1992-12-29 | — | — | US | claimed |
| WO-1992004896-A1 | METHOD OF TREATING AUTO-IMMUNE DISEASES USING GALLIUM COMPOUNDS | THE OHIO STATE UNIVERSITY (US) | 1992-04-02 | — | — | WO | claimed |
| EP-0463126-A1 | METHODS OF ENHANCING WOUND HEALING AND TISSUE REPAIR | NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY (US) | 1992-01-02 | — | — | EP | claimed |
| WO-1991010437-A1 | METHODS OF ENHANCING WOUND HEALING AND TISSUE REPAIR | NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY (US) | 1991-07-25 | — | — | WO | claimed |
| US-4935223-A | PULSING ELECTRICAL FIELD RENDERS MEMBRANE PERMEABLE TO LABELING MATERIAL; ADMINISTERING LABELED CELLS TO A PATIENT AND MONITORING | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1990-06-19 | — | — | US | claimed |
| EP-0109564-B1 | THE USE OF GALLIUM SALTS FOR THE MANUFACTURE OF PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DISORDERS OF CALCIUM HOMEOSTASIS | Sloan-Kettering Institute For Cancer Research (US) | 1988-04-27 | — | — | EP | claimed |
| US-4704277-A | GALLIUM COMPOUND TO INCREASE CALCIUM ACCRETION | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1987-11-03 | — | — | US | claimed |
| US-4529593-A | Use of gallium salts to treat disorders of calcium homeostasis | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1985-07-16 | — | — | US | claimed |
| US-4448763-A | RADIOACTIVE GALLIUM AND NON-RADIOACTIVE INDIUM | THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 1984-05-15 | — | — | US | claimed |