Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.33 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | PTPRB | P23467 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 3/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3780135 | 1.00 | DYRK1A (0.33) | DYRK1AGSK3BPTPRBWNT1ATM | |
| SCHEMBL1743901 | 0.94 | GSK3B (0.33) | DYRK1AGSK3BPTPRBWNT1ATM | |
| SCHEMBL1743902 | 0.90 | GSK3B (0.30) | DYRK1AGSK3B | |
| SCHEMBL2548917 | 0.87 | PTPRB (0.34) | DYRK1AGSK3BPTPRBWNT1ATM | |
| SCHEMBL2548919 | 0.87 | PTPRB (0.34) | DYRK1AGSK3BPTPRBWNT1ATM | |
| SCHEMBL2547827 | 0.87 | PTPRB (0.37) | DYRK1AGSK3BPTPRBWNT1ATM | |
| SCHEMBL2550295 | 0.87 | AKT1 (0.40) | DYRK1AGSK3BPTPRBWNT1ATM | |
| SCHEMBL2550309 | 0.87 | AKT1 (0.40) | DYRK1AGSK3BPTPRBWNT1ATM | |
| SCHEMBL2547825 | 0.87 | PTPRB (0.37) | DYRK1AGSK3BPTPRBWNT1ATM | |
| SCHEMBL2549043 | 0.86 | DYRK1A (0.34) | DYRK1AGSK3BPTPRBWNT1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083246-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2010-07-22 | — | — | WO | disclosed |