Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.34 |
| ▸ | GSK3B | P49841 | 4/20 | 0.34 |
| ▸ | PTPRB | P23467 | 2/20 | 0.34 |
| ▸ | WNT1 | P04628 | 4/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2549038 | 1.00 | DYRK1A (0.34) | DYRK1AGSK3BPTPRBWNT1PTPN1 | |
| SCHEMBL13286102 | 0.94 | DYRK1A (0.34) | DYRK1AGSK3BPTPRBWNT1PTPN1 | |
| SCHEMBL12241747 | 0.94 | DYRK1A (0.34) | DYRK1AGSK3BPTPRBWNT1PTPN1 | |
| SCHEMBL2547825 | 0.87 | PTPRB (0.37) | DYRK1AGSK3BPTPRBWNT1PTPN1 | |
| SCHEMBL2550309 | 0.87 | AKT1 (0.40) | DYRK1AGSK3BPTPRBWNT1ATM | |
| SCHEMBL2550295 | 0.87 | AKT1 (0.40) | DYRK1AGSK3BPTPRBWNT1ATM | |
| SCHEMBL2547827 | 0.87 | PTPRB (0.37) | DYRK1AGSK3BPTPRBWNT1PTPN1 | |
| SCHEMBL3780133 | 0.86 | DYRK1A (0.33) | DYRK1AGSK3BPTPRBWNT1PTPN1 | |
| SCHEMBL2548917 | 0.86 | PTPRB (0.34) | DYRK1AGSK3BPTPRBWNT1PTPN1 | |
| SCHEMBL2548919 | 0.86 | PTPRB (0.34) | DYRK1AGSK3BPTPRBWNT1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263647-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263647-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | TFEB, PCK2, JAK2 | DYRK1A 2916/4885GSK3B 145/4885PTPRB 879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.