Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 20/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 18/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 15/20 | 0.64 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.55 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | TACR1 | P25103 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3780905 | 1.00 | CHRM3 (0.64) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL2996197 | 0.95 | CHRM3 (0.62) | CHRM3CHRM2CHRM1 | |
| Trifluoroacetic Acid SCHEMBL2484651 | 0.93 | CHRM3 (0.56) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Trifluoroacetic Acid SCHEMBL2514225 | 0.88 | CHRM3 (0.55) | CHRM3CHRM2CHRM1 | |
| Trifluoroacetic Acid SCHEMBL16020750 | 0.88 | CHRM3 (0.55) | CHRM3CHRM2CHRM1 | |
| SCHEMBL5976167 | 0.87 | CHRM3 (0.63) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL13240898 | 0.85 | CHRM3 (0.46) | CHRM3CHRM2CHRM1 | |
| SCHEMBL71824 | 0.83 | CHRM3 (0.74) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL3787176 | 0.81 | CHRM3 (0.45) | CHRM3CHRM2CHRM1 | |
| SCHEMBL3787178 | 0.81 | CHRM3 (0.45) | CHRM3CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376489-B1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMA SPA (IT) | 2015-04-22 | — | — | EP | claimed |
| US-8835682-B2 | Alkaloid aminoester derivatives and medicinal composition thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-09-16 | — | — | US | disclosed |
| EP-2206712-A1 | \"Alkaloid aminoester derivatives and medicinal composition thereof\ | CHIESI FARMACEUTICI S.p.A. (IT) | 2010-07-14 | — | — | EP | disclosed |