Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 17/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 16/20 | 0.45 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3787178 | 1.00 | CHRM3 (0.45) | CHRM3CHRM2TYRCHRM1NPSR1 | |
| Trifluoroacetic Acid SCHEMBL2994330 | 0.92 | CHRM3 (0.42) | CHRM3CHRM2TYRCHRM1NPSR1 | |
| SCHEMBL3785620 | 0.87 | CHRM3 (0.49) | CHRM3CHRM2CHRM1 | |
| SCHEMBL3785626 | 0.87 | CHRM3 (0.49) | CHRM3CHRM2CHRM1 | |
| SCHEMBL13240898 | 0.85 | CHRM3 (0.46) | CHRM3CHRM2TYRCHRM1 | |
| SCHEMBL3782039 | 0.84 | CHRM3 (0.42) | CHRM3CHRM2CHRM1NPSR1 | |
| SCHEMBL13282721 | 0.84 | CHRM3 (0.42) | CHRM3CHRM2CHRM1NPSR1 | |
| SCHEMBL3775856 | 0.84 | CHRM3 (0.42) | CHRM3CHRM2CHRM1NPSR1 | |
| SCHEMBL3775862 | 0.84 | CHRM3 (0.42) | CHRM3CHRM2CHRM1NPSR1 | |
| Bromide SCHEMBL2542613 | 0.83 | CHRM3 (0.44) | CHRM3CHRM2CHRM1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376489-B1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMA SPA (IT) | 2015-04-22 | — | — | EP | claimed |
| US-8835682-B2 | Alkaloid aminoester derivatives and medicinal composition thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-09-16 | — | — | US | disclosed |
| US-20130196978-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-08-01 | — | — | US | disclosed |
| US-8455646-B2 | Alkaloid aminoester derivatives and medicinal composition thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-06-04 | — | — | US | disclosed |
| EP-2206712-A1 | \"Alkaloid aminoester derivatives and medicinal composition thereof\ | CHIESI FARMACEUTICI S.p.A. (IT) | 2010-07-14 | — | — | EP | disclosed |
| US-20100173880-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130196978-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHRM3, CHRM1, CHRNG | CHRM3 1/4885CHRM2 4/4885TYR 3454/4885 |
| US-20100173880-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHRM3, CHRM1, CHRNG | CHRM3 1/4885CHRM2 4/4885TYR 3454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.