Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 20/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 18/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 18/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12014465 | 1.00 | CHRM3 (0.47) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL13240904 | 1.00 | CHRM3 (0.47) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL13241020 | 0.94 | CHRM3 (0.44) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL13240948 | 0.94 | CHRM3 (0.44) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Trifluoroacetic Acid SCHEMBL2513935 | 0.93 | CHRM3 (0.42) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Trifluoroacetic Acid SCHEMBL2991213 | 0.93 | CHRM3 (0.42) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL2978743 | 0.93 | CHRM3 (0.44) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL2482975 | 0.93 | CHRM3 (0.44) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL13241019 | 0.93 | CHRM3 (0.47) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL16020668 | 0.93 | CHRM3 (0.47) | CHRM3CHRM2CHRM1CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376489-B1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMA SPA (IT) | 2015-04-22 | — | — | EP | claimed |
| US-8835682-B2 | Alkaloid aminoester derivatives and medicinal composition thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-09-16 | — | — | US | disclosed |
| US-8835682-B2 | Alkaloid aminoester derivatives and medicinal composition thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-09-16 | — | — | US | disclosed |
| US-8835682-B2 | Alkaloid aminoester derivatives and medicinal composition thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-09-16 | — | — | US | disclosed |
| US-20130196978-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-08-01 | — | — | US | disclosed |
| US-20130196978-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-08-01 | — | — | US | disclosed |
| US-8455646-B2 | Alkaloid aminoester derivatives and medicinal composition thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-06-04 | — | — | US | disclosed |
| US-20120220557-A1 | LIQUID PROPELLANT-FREE FORMULATION COMPRISING AN ANTIMUSCARINIC DRUG | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-08-30 | — | — | US | disclosed |
| WO-2012110462-A1 | LIQUID PROPELLANT-FREE FORMULATION COMPRISING AN ANTIMUSCARINIC DRUG | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-08-23 | — | — | WO | disclosed |
| EP-2206712-A1 | \"Alkaloid aminoester derivatives and medicinal composition thereof\ | CHIESI FARMACEUTICI S.p.A. (IT) | 2010-07-14 | — | — | EP | disclosed |
| EP-2206712-A1 | \"Alkaloid aminoester derivatives and medicinal composition thereof\ | CHIESI FARMACEUTICI S.p.A. (IT) | 2010-07-14 | — | — | EP | disclosed |
| US-20100173880-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2010-07-08 | — | — | US | disclosed |
| WO-2010072338-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2010-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130196978-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHRM3, CHRM1, CHRNG | CHRM3 1/4885CHRM2 4/4885CHRM1 2/4885 |
| US-20120220557-A1 | LIQUID PROPELLANT-FREE FORMULATION COMPRISING AN ANTIMUSCARINIC DRUG | CHRM3, CHRM2, ADRB2 | CHRM3 1/4885CHRM2 2/4885CHRM1 4/4885 |
| US-20100173880-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHRM3, CHRM1, CHRNG | CHRM3 1/4885CHRM2 4/4885CHRM1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.